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Key Documents

SAB4301075

Sigma-Aldrich

Anti-DGAT1 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

ARAT, ARGP1, DGAT

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

55 kDa

reatividade de espécies

rat, mouse, human

concentração

2.8 mg/mL

técnica(s)

immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)

Isotipo

IgG

nº de adesão

NP_036211.2

nº de adesão UniProt

O75907

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... DGAT1(8694)

Descrição geral

Diacylglycerol-acyltransferase 1 (DGAT1), a transmembrane protein, is a member of the membrane-bound O-acyltransferase superfamily. It is seen in the endoplasmic reticulum of several cells. DGAT1 is ubiquitously expressed in humans. A high level of mRNA is seen in the small intestine. It has three transmembrane domains. The DGAT1 gene is mapped to human chromosome 8q24.3.

Especificidade

The antibody detects endogenous levels of total DGAT1 protein.

Imunogênio

Synthetic peptide corresponding to a region derived from internal residues of human diacylglycerol O-acyltransferase 1

Aplicação

Anti-DGAT1 antibody produced in rabbit has been used in immunoblotting.

Ações bioquímicas/fisiológicas

Diacylglycerol-acyltransferase 1 (DGAT1) converts diacylglycerol and fatty acyl-CoA to triacylglycerol. It participates in energy storage. DGAT1 plays a key role in cancer progression. Activity of DGAT1 is essential for the physiologic absorption of vitamin D. Absence of DGAT1 activity is linked with body weight and adiposity reduction, and increased insulin sensitivity. Aberrations in the DGAT1 gene are associated with congenital diarrheal disorder (CDD).

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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A Mercadé et al.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 122(3), 161-164 (2005-09-01)
DGAT1 is a microsomal enzyme that catalyses the final step in triglycerides synthesis. DGAT1-deficient mice are viable, lean, fertile and resistant to diet induced obesity. We have previously identified a quantitative trait loci (QTL) on chromosome 4 that affects fatty
Aditi Gupta et al.
European journal of medical genetics, 63(4), 103817-103817 (2019-11-30)
DGAT1, a gene encoding a protein involved in lipid metabolism, has been recently implicated in causing a rare nutritional and digestive disease presenting as Congenital Diarrheal Disorder (CDD). Genetic causes of malnutrition can be classified as metabolic disorders, caused by
Ping He et al.
BMC cancer, 21(1), 252-252 (2021-03-23)
Diacylglycerol-acyltransferase 1 (DGAT1) plays an important role in the energy storage and is involved in cancer progression. A growing number of evidences showed that elevated expression of DGAT1 in cancer tissue indicated a poor outcome in cancer patients. However, the

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