MAB2637

Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1

clone HMb3-1, from hamster(Armenian)

• Sinônimo(s): CD61 antigen, Platelet membrane glycoprotein IIIa, integrin beta chain, beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), platelet glycoprotein IIIa, GPIIIa
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: hamster (Armenian)
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: HMb3-1, monoclonal
• reatividade de espécies: mouse
• técnica(s): flow cytometry: suitable; immunohistochemistry: suitable
• Isotipo: IgG
• nº de adesão NCBI: NP_058060.2
• nº de adesão UniProt: O54890
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: mouse ... Itgb3(16416)

Descrição

Descrição geral

The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented.

Platelet membrane glycoprotein Integrin beta3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets.

Especificidade

The antibody recognizes Integrin beta-3.

Imunogênio

Recombinant protein corresponding to mouse Integrin beta-3.

Aplicação

Detect Integrin beta-3 (CD61) using this Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 validated for use in FC, IH.

Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Piali, 1995).

Qualidade

Evaluated by Flow Cytometry on mouse bone marrow-derived cells.

Flow Cytometry Analysis: 0.1-1 µg/mL of the antibody detected Integrin beta-3 on mouse bone marrow-derived cells

Descrição-alvo

~ 86-87 kDa

forma física

Format: Purified

Nota de análise

Control
Mouse bone marrow-derived cells

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable