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Documentos Principais

SAB4300647

Sigma-Aldrich

Anti-GFAP antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Anti-FLJ45472

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

peso molecular

~50 kDa

reatividade de espécies

rat, human

concentração

1 mg/mL

técnica(s)

western blot: 1:500-1:1000

Isotipo

IgG

sequência de imunogênio

(E-S-K-Q-E)

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... GFAP(2670)

Descrição geral

Glial fibrillary acidic protein (GFAP) is an intermediate-filament protein found in the astrocytes of CNS (central nervous system).{56,59} It is located on chromosome 17q21.

The antibody detects endogenous level of total GFAP protein.

Imunogênio

Peptide sequence around aa. 423-427 (E-S-K-Q-E), according to the protein NP_002046.1

Ações bioquímicas/fisiológicas

Glial fibrillary acidic protein (GFAP) regulates intermediate filament network dynamics, cell morphology and focal adhesions. It helps in maintaining myelination and stability of CNS (central nervous system) white matter architecture.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Certificados de análise (COA)

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GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination
Liedtke W, et al.
Neuron (1996)
GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions
Moeton M, et al.
Cellular and Molecular Life Sciences (2016)
Childhood constipation; an overview of genetic studies and associated syndromes
Peeters B, et al.
Best Practice & Research. Clinical Gastroenterology (2011)
Lin Wang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(4), 1535-1559 (2018-10-31)
Neurotoxic A1 astrocytes are induced by inflammation after spinal cord injury (SCI), and the inflammation-related Nuclear Factor Kappa B (NFκB) pathway may be related to A1-astrocyte activation. Mesenchymal stem cell (MSC) transplantation is a promising therapy for SCI, where transplanted
Aditi Swarup et al.
Experimental eye research, 172, 45-53 (2018-04-01)
The primary energy substrate of the lens is glucose and uptake of glucose from the aqueous humor is dependent on glucose transporters. GLUT1, the facilitated glucose transporter encoded by Slc2a1 is expressed in the epithelium of bovine, human and rat

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