C9205
Anticorpo monoclonal anti-proteína ácida fibrilar glial (GFAP)
clone G-A-5, purified from hybridoma cell culture
Sinônimo(s):
Anti-GFAP
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
CY3 conjugate
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
G-A-5, monoclonal
forma
buffered aqueous solution
reatividade de espécies
human, pig, rat
técnica(s)
direct immunofluorescence: 1:400 using alcohol-fixed, paraffin-embedded rat brain sections
Isotipo
IgG1
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... GFAP(2670)
rat ... Gfap(24387)
Procurando produtos similares? Visita Guia de comparação de produtos
Descrição geral
Monoclonal Anti-Glial Fibrillary Acidic Protein (GFAP) (mouse IgG1 isotype) conjugated to Cy3 is a purified mouse monoclonal antibody conjugated to Cy3 reactive dye. It is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. GFAP, in the central nervous system, is found in developing, normal, reactive and neoplastic astrocytes and ependymal cells. It is expressed in developing oligodendrocytes in the peripheral nervous system. GFAP is found in some Schwann cells, enteric glial cells, Müller glia of the retina, and the satellite cells of human sensory ganglia. It has been demonstrated in some non-glial cells as well.
Especificidade
O anticorpo reage especificamente com GFAP em ensaios de immunoblotting e marca astrócitos, células gliais de Bergmann e condrócitos de cartilagem elástica em coloração imuno-histoquímica. O anticorpo reage com o antígeno glial específico em cortes de tecido congelados ou fixados em álcool.
The antibody reacts specifically with GFAP in immunoblotting assays and labels astrocytes, and chondrocytes of elastic cartilage in immunohistochemical staining. The antibody reacts with glial specific antigen in frozen or alcohol-fixed tissue sections.
Imunogênio
GFAP da medula óssea de suínos
GFAP from pig spinal cord
Aplicação
Monoclonal Anti-Glial Fibrillary Acidic Protein (GFAP) (mouse IgG1 isotype) conjugated to Cy3 has been used in
- immunohistochemistry
- immunoblotting
- immunolabelling,
- immunocytochemistry
- immunofluorescence
Ações bioquímicas/fisiológicas
Glial Fibrillary Acidic Protein (GFAP) is expressed in several glial-related intracranial neoplasms such as astrocytomas and to a variable extent in ependymomas, medulloblastomas, choroid plexus papillomas, gangliogliomas, mixed gliomas, hemangioblastomas, pineocytomas, pineoblastomas, pituitary adenomas, retinoblastomas, oligodendrogliomas and in a small minority of peripheral nerve sheath tumors (schwannomas and neurofibromas). It may also be found in pleomorphic adenomas and ovarian and testicular teratomas.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide
Informações legais
Cy is distributed under license from Amersham Biosciences Limited.
Cy3 is a trademark of Cytiva
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Não está encontrando o produto certo?
Experimente o nosso Ferramenta de seleção de produtos.
produto relacionado
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Os clientes também visualizaram
D B Pettigrew et al.
BMC neuroscience, 2, 9-9 (2001-06-12)
Brain and spinal cord white matter can support extensive axonal growth. This growth is generally constrained to an orientation that is parallel to the longitudinal axis of the fiber tract. This constraint is presumably due to permissive and non-permissive substrates
Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex
Drexel M, et al.
Neuropharmacology, 63(5), 806-817 (2012)
Aixa F Rivera-Pagán et al.
PloS one, 10(4), e0125195-e0125195 (2015-04-18)
Excitotoxicity due to glutamate receptor over-activation is one of the key mediators of neuronal death after an ischemic insult. Therefore, a major function of astrocytes is to maintain low extracellular levels of glutamate. The ability of astrocytic glutamate transporters to
Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo
Hainfellner JA, et al.
Journal of Neuropathology and Experimental Neurology, 60(5), 449-461 (2001)
Expression of vimentin and glial fibrillary acidic protein in central nervous system development of rats
Luo H, et al.
Asian Pacific Journal of Tropical Medicine, 10(12), 1185-1189 (2017)
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica