SAB4200797

Anti-HSP70 antibody produced in rabbit

IgG fraction of antiserum

• Sinônimo(s): Anti-Heat shock 70 kDa protein
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• forma do anticorpo: IgG fraction of antiserum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: ~70 kDa
• reatividade de espécies: chicken, rat, canine, human, monkey, mouse, bovine
• técnica(s): immunoblotting: 1:250-1:500 using different cell extracts; immunoprecipitation (IP): 10-20 μg/test
• nº de adesão UniProt: P0DMV8
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... HSPA1A(3303)

Descrição

Descrição geral

Heat Shock Proteins 70 (HSP70), also known as HSPA1A (heat shock protein family A (Hsp70) member 1A) or HSPA1B (heat shock protein family A (Hsp70) member 1B) is encoded by the gene mapped to human chromosome 6p21.3. xHSP70 is a highly conserved protein family with four members such as the constitutive (or cognate) HSP73, the stress-inducible HSP72, the glucose regulated proteins (grp)78 and grp75. During heat shock, HSP70s concentrate in the cell nuclei and return to the cytoplasm when the shock is removed.

Imunogênio

Synthetic peptide from the internal region of human HSP70 protein, conjugated to KLH

Aplicação

The antibody has been used in various immunochemical techniques including immunoblotting (∼70 kDa) and immunoprecipitation.Detection of the HSP70 band by Immunoblotting is specifically inhibited by the immunogen.

Ações bioquímicas/fisiológicas

Heat Shock Proteins 70 (HSP70) plays a key role in stress response, including heat stress, in every organism in which the proteins have been examined. These proteins also facilitates a wide range of folding processes, including the folding and assembly of newly synthesized proteins, refolding of misfolded and aggregated proteins, membrane translocation of organellar and secretory proteins, and control of the activity of regulatory proteins. In addition, HSP70 also play a cytoprotective role in neurodegenerative diseases such as Alzheimer′s, Parkinson′s, Huntington′s, ALS and others. Unregulated expression of HSP70s leads to the development of several types of cancer, such as malignant melanoma and renal cell cancer.

forma física

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Outras notas

This product is for R&D use only, not for drug, household, or other uses.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable