SAB4200780
Anti-Human IgM (μ-chain specific) antibody, Mouse monoclonal
clone MB-11, purified from hybridoma cell culture
Sinônimo(s):
Anti-Human immunoglobulin M
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.46
clone:
MB-11, monoclonal
application:
ELISA
reatividade de espécies:
human
técnica(s):
ELISA: 0.1-0.2 μg/mL using 2.5 μg/mL Human IgM myeloma for coating
immunoblotting: suitable
immunoblotting: suitable
citations:
1
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified from hybridoma cell culture
tipo de produto de anticorpo
primary antibodies
clone
MB-11, monoclonal
Formulário
buffered aqueous solution
reatividade de espécies
human
concentração
~1.0 mg/mL
técnica(s)
ELISA: 0.1-0.2 μg/mL using 2.5 μg/mL Human IgM myeloma for coating
immunoblotting: suitable
Isotipo
IgG2b
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Descrição geral
Anti-Human IgM (m-chain specific) antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MB-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgM protein.
Immunoglobulin M (IgM) is the major class of surface immunoglobulins on lymphocyte membranes. IgM is suggested to act as the first line of defense during microbial infections. IgM has a pentameric structure, in which monomers are linking together via disulfide bonds. Surface IgM is expressed on immature and mature B cells, whereas IgM heavy chain is expressed intracellularly in pre-B cells. IgM serves as the antigen receptor of naive B cells and is involved in B cell maturation and complement activation.
Especificidade
Anti-Human IgM (m-chain specific) antibody, Mouse monoclonal specifically recognizes m chain of Human IgM. The antibody shows no cross-reactivity with human IgG, Fab, Fc, k, l, and g chains.
Imunogênio
Purified human IgM
Aplicação
The antibody is recommended to use in various immunological techniques, including ELISA and Immunoblot.
Ações bioquímicas/fisiológicas
Immunoglobulin M (IgM) acts as an antigen specific part of the B cell antigen receptor on the surface of B lymphocytes that are not stimulated, in its monomeric form. Polymeric IgM molecules also serve as important activators of the classical complement cascade. IgM is essential in agglutination and cytolytic reactions. IgM serves as the antigen receptor of naive B cells and is involved in B cell maturation and complement activation.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.
Outras notas
This product is for R&D use only, not for drug, household, or other uses.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Immunobiology: The Immune System in Health and Disease
Janeway, CA Jr. et al.
Immunobiology: The Immune System in Health and Disease (2001)
The Immunoglobulins: Structure and Function (1998)
Leman Yel et al.
International archives of allergy and immunology, 150(3), 291-298 (2009-06-06)
IgM deficiency is a dysgammaglobulinemia characterized by isolated low levels of serum IgM. Patients with IgM deficiency may exhibit various clinical manifestations. However, IgM deficiency still remains to be explored with regard to diagnosis and treatment. Through a retrospective chart
Chloe C McAlister et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 10(2), 315-319 (2004-02-06)
The mechanism by which a liver transplantation might protect a simultaneous kidney transplant in a crossmatch-positive recipient is unknown. Flow cytometry crossmatch (FCXM) has increased the sensitivity of donor-specific antibody (DSA) detection compared with complement-dependant cytotoxicity (CDC). Here we compare
L D Notarangelo et al.
Immunodeficiency reviews, 3(2), 101-121 (1992-01-01)
Immunodeficiency with hyper-IgM (HIM) is a rare disorder characterized by recurrent infections associated with low IgG and IgA, and normal to increased IgM serum levels. Both primary and secondary forms of HIM syndrome have been reported. Among primary HIM syndrome
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