SAB4200129

Anti-Phospholipase A2 (iPLA2) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• Sinônimo(s): Anti-CaI-PLA2, Anti-GVI, Anti-INAD1, Anti-IPLA2-VIA, Anti-PARK14, Anti-PLA2, Anti-PLA2G6, Anti-PNPLA9, Anti-Phospholipase A2, group VI (cytosolic, calcium-independent), Anti-iPLA2
• Número MDL: MFCD00803786
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: ~85 kDa (and ~95 kDa human iPLA2 and ~95 kDa mouse and rat iPLA2.)
• reatividade de espécies: human, mouse, rat
• concentração: ~1.5 mg/mL
• técnica(s): western blot: 1.5-3.0 μg/mL using using extracts of HEK-293T cells overexpressing human iPLA₂, RAW264 cell lysates and rat pancreas extracts (S1 fraction).
• nº de adesão UniProt: O60733
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... PLA2G6(8398) ; mouse ... pla2g6(53357) ; rat ... pla2g6(360426)

Descrição

Descrição geral

Calcium-independent phospholipase A2 (iPLA2) belongs to the group six of phospholipase A2 (PLA2) enzymes. The protein is encoded by the gene mapped to human chromosome 22q13.1. iPLA2 is an intracellular enzyme. It is present both in the cytosol and in membrane fractions. The encoded protein contains 752 amino acids and has a mass of 85kDa. It is characterized with a eight ankyrin repeats and a catalytic domain.

Aplicação

Anti-Phospholipase A2 (iPLA2) antibody produced in rabbit has been used in western blotting.

Ações bioquímicas/fisiológicas

Calcium-independent phospholipase A2 (iPLA2) in the absence of Ca²⁺, catalyzes the hydrolysis of the Sn-2 ester bond in phospholipids to produce free fatty acids and lysophospholipids. iPLA2 might play an essential role in activating the receptor-mediated signaling pathway. Additionally, it also yields precursors for bioactive compounds such as eicosanoid and platelet-activating factor. The encoded protein performs housekeeping role in phospholipid remodeling.

forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable