SAB3500196
Anti-CTRP6 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinônimo(s):
Anti-CTRP6
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
reatividade de espécies
human, mouse
técnica(s)
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... C1QTNF6(114904)
Descrição geral
C1q and TNF (Tumour necrosis factor) related protein 6 (CTRP6/C1QTNF6) is a glycoprotein which belongs to family of proteins containing TNF alpha-like globular domain. CTRP6 is a single peptide with a short variable region, a collagen like region, and a C-terminal globular domain. CTRP6 is expressed in human synoviocytes. In human chromosome, the gene is localized on 22q12.3.
Imunogênio
CTRP6 antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human CTRP6.
Ações bioquímicas/fisiológicas
C1q and TNF (Tumour necrosis factor) related protein 6 (CTRP6) plays a major role in fatty acid metabolism. CTRP6 phosphorylates AMCK (5′-AMP (adenosine monophosphate)-activated protein kinase) and ACC (acetyl coenzyme A carboxylase) and activates AMCK-ACC pathway. The expression level of CTRP6 is increased in rheumatoid arthritis. CTRP6 inhibits alternative complement pathway and helps in maintaining pregnancy. CTRP6 mediates the ectopic lipogenesis in myoblasts through AdipoR1/Erk/PPARγ (Adiponectin receptor 1/Extracellular signal-regulated kinases/Peroxisome proliferator-activated receptor gamma) signalling pathway. CTRP6 is overexpressed in hepatocellular carcinoma and stimulates angiogenesis by Akt (serine/threonine-protein kinase) pathway. CTRP6 confers susceptibility to type I diabetes. CTRP6 maybe a key regulator connecting obesity with tissue inflammation and insulin resistance.
Características e benefícios
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Ligação
The action of this antibody can be blocked using blocking peptide SBP3500196.
forma física
Supplied in PBS with 0.02% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Preços
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance
Lei X, et al.
The Journal of Biological Chemistry, 292(36), 14836-14850 (2017)
Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPAR gamma signalling pathway
Wu W, et al.
Acta biochimica et biophysica Sinica, 48(6), 509-519 (2016)
Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma
Takeuchi T, et al.
Analytical Cellular Pathology, 34(3), 113-121 (2011)
Masanori A Murayama et al.
Nature communications, 6, 8483-8483 (2015-09-26)
The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models.
Wan Lee et al.
FEBS letters, 584(5), 968-972 (2010-01-28)
C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the
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