Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

S5068

Sigma-Aldrich

Salmeterol xinafoate

≥98% (HPLC), solid

Sinônimo(s):

(±) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate, GR 33343X xinafoate

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C25H37NO4 · C11H8O3
Número CAS:
94749-08-3
Peso molecular:
603.75
Número MDL:
MFCD00897708
Código UNSPSC:
12352200
ID de substância PubChem:
24278713
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

cor

white

solubilidade

H2O: slightly soluble
ethanol: slightly soluble
methanol: freely soluble

originador

GlaxoSmithKline

cadeia de caracteres SMILES

OC(=O)c1ccc2ccccc2c1O.OCc3cc(ccc3O)C(O)CNCCCCCCOCCCCc4ccccc4

InChI

1S/C25H37NO4.C11H8O3/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21;12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2;1-6,12H,(H,13,14)

chave InChI

XTZNCVSCVHTPAI-UHFFFAOYSA-N

Informações sobre genes

human ... ADRB2(154)

Procurando produtos similares? Visita Guia de comparação de produtos

Aplicação

Salmeterol xinafoate was used as conjugate with human serum albumin to study the immune responses in rabbits.7

Ações bioquímicas/fisiológicas

Salmeterol xinafoate is a β2 adrenoceptor agonist with longer lasting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles, stabilizes mast cells and regulates the release of histamine. Salmetrol is particularly effective in treatment of mild asthma, chronic obstructive pulmonary disorder.5,6
β2-adrenoceptor agonist.

Características e benefícios

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 7

1 of 7

Ipratropium bromide monohydrate ≥98% (TLC), powder

Sigma-Aldrich

I1637

Ipratropium bromide monohydrate

1-Hydroxy-2-naphthoic acid ≥97.0%

Sigma-Aldrich

109630

1-Hydroxy-2-naphthoic acid

Ritodrine hydrochloride

Sigma-Aldrich

R0758

Ritodrine hydrochloride

Budesonide ≥99%

Sigma-Aldrich

B7777

Budesonide

Bisoprolol hemifumarate salt ≥98% (HPLC), solid

Sigma-Aldrich

B2185

Bisoprolol hemifumarate salt

Formoterol fumarate dihydrate European Pharmacopoeia (EP) Reference Standard

F0372000

Formoterol fumarate dihydrate

Levalbuterol hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0138

Levalbuterol hydrochloride

Robert J Slack et al.
The Journal of pharmacology and experimental therapeutics, 344(1), 218-230 (2012-11-08)
Vilanterol trifenatate (vilanterol) is a novel, long-acting β(2)-adrenoceptor (β(2)-AR) agonist with 24 h activity. In this study, we describe the preclinical pharmacological profile of vilanterol using radioligand binding and cAMP studies in recombinant assays as well as human and guinea
M Isogaya et al.
Molecular pharmacology, 54(4), 616-622 (1998-10-10)
Transmembrane domains (TMDs) I, II, and VII of the beta2-adrenergic receptor (beta2AR) were replaced, individually or in combination, with the corresponding regions of the beta1AR, and vice versa. The beta2-selective binding of salmeterol was not affected by the exchange of
Christopher J Cates et al.
The Cochrane database of systematic reviews, 10, CD010005-CD010005 (2012-10-19)
Two large surveillance studies in adults with asthma have found an increased risk of asthma-related mortality in those who took regular salmeterol as monotherapy in comparison to placebo or regular salbutamol. No similar sized surveillance studies have been carried out
Adam Barczyk et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 33(196), 187-192 (2013-01-01)
Chronic obstructive pulmonary disease (COPD) is one of the most important diseases because of high and constantly increasing prevalence, morbidity and mortality. An update of the Global strategy for the diagnosis, management, and prevention of COPD - GOLD report was
Terence L Fodey et al.
Analytica chimica acta, 637(1-2), 328-332 (2009-03-17)
Haptens are low molecular weight compounds that are non-immunogenic and so must be conjugated to carrier molecules to elicit an immune response. Doses of 50-1000 microg protein conjugate have been suggested for immunisation of rabbits with hapten-protein immunogens. Although larger
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica