R1903

RS 102895 hydrochloride

≥98% (HPLC), powder

• Sinônimo(s): 1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one
• Fórmula empírica (Notação de Hill): C₂₁H₂₁F₃N₂O₂ · HCl
• Peso molecular: 426.86
• Número MDL: MFCD08703093
• Código UNSPSC: 12352202
• ID de substância PubChem: 24724588
• NACRES: NA.32

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• peso molecular: 426.86 g/mol
• embalagem: pkg of 5 mg
• condição de armazenamento: desiccated
• cor: white
• solubilidade: DMSO: >10 mg/mL
• temperatura de armazenamento: 20-25°C
• cadeia de caracteres SMILES: Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1
• InChI: 1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
• chave InChI: KRRISOFSWVKYBF-UHFFFAOYSA-N

Descrição

Descrição geral

RS 102895 hydrochloride is a small molecule antagonist of C-C motif chemokine receptor 2 (CCR2) which belongs to the spiropiperidine (SP) class.

Aplicação

RS 102895 hydrochloride has been used in bromodeoxyuridine (5-bromo-2′-deoxyuridine, BrdU) cell proliferation assay to study effect of IL33 (interleukin 33) on decidual stromal cell proliferation in present of the antagonist and to study the effects of antagonists on the accumulation of bone marrow-derived microglia.

Ações bioquímicas/fisiológicas

RS 102895 hydrochloride has a high affinity to the β subunit of the C-C motif chemokine receptor 2 (CCR2) and binds specifically to it. This results in the inhibition of CCR2 signaling. It also suppresses monocyte recruitment. Hence, RS 102895 may be useful for obstructing the immune suppressive effects of monocytes during early vaccine responses.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)