PZ0250

PF-04859989 hydrochloride

≥98% (HPLC)

• Sinônimo(s): (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one; L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride, PF-4859989 hydrochloride, PF04859989 hydrochloride
• Fórmula empírica (Notação de Hill): C₉H₁₀N₂O₂ · HCl
• Número CAS: 177943-33-8
• Peso molecular: 214.65
• Número MDL: MFCD22419400
• Código UNSPSC: 51111800
• ID de substância PubChem: 329823792
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: H₂O: 20 mg/mL, clear
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl
• InChI: 1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1
• chave InChI: WZOBDOKCHIUXAY-FJXQXJEOSA-N

Descrição

Ações bioquímicas/fisiológicas

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC₅₀ values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable