420360-M

KMO Inhibitor I, Ro 61-8048

The KMO Inhibitor I, Ro 61-8048, also referenced under CAS 199666-03-0, controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinônimo(s): KMO Inhibitor I, Ro 61-8048, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide
• Fórmula empírica (Notação de Hill): C₁₇H₁₅N₃O₆S₂
• Número CAS: 199666-03-0
• Peso molecular: 421.45
• Número MDL: MFCD11040807
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: DMSO: 100 mg/mL; ethanol: 12.5 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [S](=O)(=O)(Nc2[s]cc(n2)c3cc(ccc3)[N+](=O)[O-])c1cc(c(cc1)OC)OC
• InChI: 1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)
• chave InChI: NDPBMCKQJOZAQX-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (K_i = 4.8 nM; IC₅₀ = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361).

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Campesan, S., et al. 2011. Chem. Biol.21, 961.
Zwilling, D., et al. 2011. Cell145, 863.
Giorgini, F., et al. 2005. Nat. Genet.37, 526.
Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab.19, 771,
Rover, S., et al. 1997. J. Med. Chem.40, 4378.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3