P6532

Prostaglandin E₂

γ-irradiated, powder, BioXtra, suitable for cell culture

• Sinônimo(s): (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, Dinoprostone, PGE₂
• Fórmula empírica (Notação de Hill): C₂₀H₃₂O₅
• Número CAS: 363-24-6
• Peso molecular: 352.47
• Beilstein: 4709356
• Número CE: 206-656-6
• Número MDL: MFCD00077861
• Código UNSPSC: 12352209
• eCl@ss: 42020658
• ID de substância PubChem: 24898775
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• esterilidade: γ-irradiated
• linha de produto: BioXtra
• forma: powder
• potência: 0.25-100 ng/mL
• técnica(s): cell culture | mammalian: suitable
• solubilidade: ethanol: 1 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O
• InChI: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
• chave InChI: XEYBRNLFEZDVAW-ARSRFYASSA-N
• Informações sobre genes: human ... PTGER1(5731) , PTGER2(5732) , PTGER3(5733) , PTGER4(5734) , PTGIR(5739) ; mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

Descrição

Aplicação

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.

Prostaglandin E2 has been used to determine its effects on collagen gel contraction mediated by alveolar cell carcinoma cell line A549.

Ações bioquímicas/fisiológicas

Most biologically active prostaglandin. PGE₂ induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE₂-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE₂ on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.

forma física

powder -20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H360FD
• Declarações de precaução: P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges