P5624

PD-118057

≥98% (HPLC), solid

• Sinônimo(s): 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid
• Fórmula empírica (Notação de Hill): C₂₁H₁₇Cl₂NO₂
• Número CAS: 313674-97-4
• Peso molecular: 386.27
• Número MDL: MFCD08705328
• Código UNSPSC: 12352200
• ID de substância PubChem: 24724580
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: solid
• cor: light yellow
• solubilidade: DMSO: 9 mg/mL
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC(=O)c1ccccc1Nc2ccc(CCc3ccc(Cl)c(Cl)c3)cc2
• InChI: 1S/C21H17Cl2NO2/c22-18-12-9-15(13-19(18)23)6-5-14-7-10-16(11-8-14)24-20-4-2-1-3-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26)
• chave InChI: ZCQOSCDABPVAFB-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure

Características e benefícios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335,H413
• Declarações de precaução: P273 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves