P215

PD 98,059

solid

• Sinônimo(s): 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
• Fórmula empírica (Notação de Hill): C₁₆H₁₃NO₃
• Número CAS: 167869-21-8
• Peso molecular: 267.28
• Número MDL: MFCD00671789
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278666
• NACRES: NA.77

Propriedades

• forma: solid
• Nível de qualidade: 100
• cor: yellow
• solubilidade: DMSO: 10 mg/mL, clear
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
• InChI: 1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
• chave InChI: QFWCYNPOPKQOKV-UHFFFAOYSA-N
• Informações sobre genes: human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)

Descrição

Aplicação

PD 98,059 has been used:

• in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
• in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
• in culture medium for cell migration assay

Ações bioquímicas/fisiológicas

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Características e benefícios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações legais

Sold with permission of Warner Lambert Company.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves