MAP2K4
mitogen-activated protein kinase kinase 4
Synonyms:
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Species:
Human MAP2K4 (6416), Mouse Map2k4 (26398), Rat Map2k4 (287398), domestic guinea pig Map2k4 (100733674), naked mole-rat Map2k4 (101705822), Domestic Rabbit MAP2K4 (100344852), sheep MAP2K4 (101115045), chicken MAP2K4 (417312), dog MAP2K4 (489508), cow MAP2K4 (526469) ...More
UniProtKB ID:
Gene ID:
- Human(6416) Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008]
- Mouse(26398) mitogen-activated protein kinase kinase 4
- Rat(287398) mitogen activated protein kinase kinase 4
- domestic guinea pig(100733674) mitogen-activated protein kinase kinase 4
- naked mole-rat(101705822) mitogen-activated protein kinase kinase 4
- Domestic Rabbit(100344852) mitogen-activated protein kinase kinase 4
- sheep(101115045) mitogen-activated protein kinase kinase 4
- chicken(417312) mitogen-activated protein kinase kinase 4
- dog(489508) mitogen-activated protein kinase kinase 4
- cow(526469) mitogen-activated protein kinase kinase 4
- Horse(100073094) mitogen-activated protein kinase kinase 4
- domestic cat(101086432) mitogen-activated protein kinase kinase 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MAP2K4 (Ab-80) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-phospho-SEK1/MKK4 (pThr261) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-MAP Kinase Kinase 4 (MKK4, SEK, JNKK1) (pThr223) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species