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Documentos Principais

P4562

Sigma-Aldrich

Piruvato de sódio

powder, BioXtra, suitable for mouse embryo cell culture

Sinônimo(s):

αÁcido α-cetopropiônico, Ácido 2-oxopropanoico, Ácido pirúvico

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About This Item

Fórmula linear:
CH3COCOONa
Número CAS:
Peso molecular:
110.04
Beilstein:
3568341
Número CE:
Número MDL:
Código UNSPSC:
12352207
ID de substância PubChem:
NACRES:
NA.75

linha de produto

BioXtra

Nível de qualidade

Ensaio

≥99%

Formulário

powder

técnica(s)

cell culture | embryo: suitable

pf

>300 °C (lit.)

solubilidade

H2O: 100 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

chave InChI

DAEPDZWVDSPTHF-UHFFFAOYSA-M

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Descrição geral

Pyruvate, the end-product of the glycolysis pathway, is the anion of pyruvic acid.

Aplicação

Sodium pyruvate has been used:
  • as a supplement in Ca2+ + N-Tris(hydroxymethil)methyl-2-aminoethanesulfonic acid (TES)–NaCl medium for sperm incubation
  • as a supplement in TCM-199 hepes modification solution for cumulus-oocytes complexes (COC′s) culture
  • as a supplement in Dulbecco′s modified Eagle medium (DMEM) to culture mouse primary hepatocytes (MPHs) and also to intraperitoneally inject fasted mice for glucose production assessment

Ações bioquímicas/fisiológicas

Sodium pyruvate is mainly used as a constituent in culture broth and media. It exhibits anti-oxidation and anti-inflammatory properties. Hence sodium pyruvate is considered a possible therapy for allergic rhinitis. Sodium pyruvate might also be a new approach treating lactic acidosis.
Sodium pyruvate is used by cells as an easily accessible carbohydrate source. Additionally, it is involved with amino acid metabolism and initiates the Kreb′s cycle. Sodium pyruvate attenuates oxidative stress in vitro. The 100 mM solution should be diluted at 1:100 for most cell culture applications. This product has been qualified for use in mouse embryo cultures.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Eye Irrit. 2 - Skin Sens. 1B

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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To examine the effects of sodium pyruvate (SP) on metabolic acidosis. For the in vivo experiments, we evaluated effects of SP on an ammonium chloride (NH4Cl)-induced hyperchloremic acidosis rat model. SP was infused at overall doses of 2, 4, and
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