P2141

Phalloidin Peptide

≥90% (HPLC), powder

• Sinônimo(s): 28-(2,3-dihydroxy-2-methylpropyl)-18-hydroxy-34-(1-hydroxyethyl)-23,31-dimethyl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.0^3,11.0^4,9.0^16,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone
• Fórmula empírica (Notação de Hill): C₃₅H₄₈N₈O₁₁S
• Número CAS: 17466-45-4
• Peso molecular: 788.87
• Beilstein: 4347460
• Número CE: 241-484-5
• Número MDL: MFCD03427567
• Código UNSPSC: 12352202
• ID de substância PubChem: 24898277
• NACRES: NA.32

Propriedades

• Nome do produto: Phalloidin from Amanita phalloides, ≥90%
• fonte biológica: Amanita phalloides
• Nível de qualidade: 200
• Ensaio: ≥90%
• Formulário: powder
• cadeia de caracteres SMILES: CC(O)C1NC(=O)C(C)NC(=O)C(CC(C)(O)CO)NC(=O)C2Cc3c(SCC(NC1=O)C(=O)N4CC(O)CC4C(=O)NC(C)C(=O)N2)[nH]c5ccccc35
• InChI: 1S/C35H48N8O11S/c1-15-27(47)38-22-10-20-19-7-5-6-8-21(19)41-33(20)55-13-24(34(53)43-12-18(46)9-25(43)31(51)37-15)40-32(52)26(17(3)45)42-28(48)16(2)36-30(50)23(39-29(22)49)11-35(4,54)14-44/h5-8,15-18,22-26,41,44-46,54H,9-14H2,1-4H3,(H,36,50)(H,37,51)(H,38,47)(H,39,49)(H,40,52)(H,42,48)
• chave InChI: KPKZJLCSROULON-UHFFFAOYSA-N

Descrição

Descrição geral

Phalloidin is a phallotoxin produced by death cap mushroom Amanita phalloides. It is a cyclic peptide, which interacts with actin, and this was first identified in phalloidin-poisoned rats. It is a heptapeptide, cyclic in nature, with a crosslink between tryptophan at position 6 and cysteine at position 3. The side chain of amino acid 7 (γ-δ-dihydroxyleucine) in phalloidin, is accessible to modifications, through which fluorescently labeled phalloidin compounds can be produced.

Aplicação

Phalloidin has been used:

• As a supplement in PEM buffer and dimethyl sulfoxide (DMSO).
• As a drug.
• In immunohistochemistry to stain F-actin.

Ações bioquímicas/fisiológicas

Phalloidin interacts with polymeric actin, and not oligomeric or monomeric forms. This interaction leads to highly stabilized actin filaments, which resist depolymerization and disassembly. In rats, this toxin causes death due to liver hemorrhage and cells show abnormal actin clustering. The affinity of phalloidin to actin is not significantly altered after derivatizing fluorescently labelled phalloidin compounds. These compounds can be used to study actin structure and organization within eukaryotic cells.

Phalloidin is a toxin isolated from Amanita phalloides that binds polymeric F actin, stabilizing it and interfering with the function of
actin-rich structures.

Toxin that binds polymeric F actin, stabilizing it and interfering with the function of actin-rich structures.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300 + H310 + H330
• Declarações de precaução: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Classificações de perigo: Acute Tox. 2 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable