N2288
Nefiracetam
solid
Sinônimo(s):
(2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384
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About This Item
Fórmula empírica (Notação de Hill):
C14H18N2O2
Número CAS:
Peso molecular:
246.30
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Formulário
solid
Nível de qualidade
cor
white to off-white
solubilidade
DMSO: >5 mg/mL
cadeia de caracteres SMILES
Cc1cccc(C)c1NC(=O)CN2CCCC2=O
InChI
1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
chave InChI
NGHTXZCKLWZPGK-UHFFFAOYSA-N
Ações bioquímicas/fisiológicas
Nefiracetam (NEF) is a pyrrolidonetype nootropic agent with various pharmacologic as well as cognition enhancing effects. In amygdala-kindled seizures, nefiracetam inhibits both electroencephalographic and behavioral seizures. NEF has a distinct anticonvulsant spectrum.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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[Evaluation methods for the discriminative stimulus and possible mechanisms of discriminative stimulus effects of methamphetamine in the rat].
Hiroyuki Mizoguchi et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 126(1), 17-23 (2005-09-06)
Robert G Robinson et al.
The Journal of neuropsychiatry and clinical neurosciences, 21(2), 144-151 (2009-07-23)
Nefiracetam is a novel pyrrolidone-type nootropic compound shown in preliminary trials to increase blood flow and improve patient outlook and energy following stroke. Of 137 stroke patients with major depression, 70 also met published diagnostic criteria for apathy (51.1%) and
Pharmacological study on Alzheimer's drugs targeting calcium/calmodulin-dependent protein kinase II.
Shigeki Moriguchi
Journal of pharmacological sciences, 117(1), 6-11 (2011-08-09)
In the brain of Alzheimer's disease patients, down-regulation of both cholinergic and glutamatergic systems have been found and is thought to play an important role in impairment of cognition, learning, and memory. Nefiracetam is a pyrrolidine-related nootropic drug exhibiting various
Yijin Yan et al.
Behavioural brain research, 173(1), 39-46 (2006-07-22)
Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam
Robert G Robinson et al.
The Journal of neuropsychiatry and clinical neurosciences, 20(2), 178-184 (2008-05-03)
In preliminary trials, nefiracetam, a gamma aminobutyric compound, enhanced blood flow and improved mood following stroke. Within 3 months following stroke with major depression, 159 patients were enrolled in a double-blind trial of nefiracetam or placebo. Repeated measures analysis of
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