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N2162

Sigma-Aldrich

NH125

≥98% (HPLC), solid

Sinônimo(s):

1-Benzyl-3-cetyl-2-methylimidazolium iodide

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About This Item

Fórmula empírica (Notação de Hill):
C27H45IN2
Número CAS:
278603-08-0
Peso molecular:
524.56
Número MDL:
MFCD07370143
Código UNSPSC:
12352200
ID de substância PubChem:
329818598
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

cor

white to off-white

pf

88.2-94.9 °C

solubilidade

DMSO: >20 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C

InChI

1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1

chave InChI

RVWOHCBHAGBLLT-UHFFFAOYSA-M

Ações bioquímicas/fisiológicas

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.
NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).

Embalagem

Packaged under nitrogen.

Nota de análise

IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 μM), protein kinase A (IC50= 80 μM), and calmodulin-dependent kinase II IC50 > 100 μM).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12230-12238 (2014-09-05)
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When faced with stressful conditions, people with a tendency toward impulsive aggression may suddenly hurt others. We have previously shown that the blockade of NMDA receptors (NMDARs) within the ventral hippocampus (VH) produces anti-aggressive effects. However, little is known about
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The Journal of veterinary medical science, 81(1), 35-41 (2018-11-16)
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) inhibits protein translation through the phosphorylation of its specific substrate, eEF2. We previously demonstrated that eEF2K expression increases in superior mesenteric artery from spontaneously hypertensive rats (SHR) and that eEF2K mediates development of
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Oncotarget, 8(7), 11950-11962 (2017-01-07)
Hepatocellular carcinoma is a cancer with increasing incidence and largely refractory to current anticancer drugs. Since Sorafenib, a multikinase inhibitor has shown modest efficacy in advanced hepatocellular carcinoma additional treatments are highly needed. Protein phosphorylation via kinases is an important
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