N1790

Naftifine hydrochloride

• Sinônimo(s): Naftifine HCL
• Fórmula empírica (Notação de Hill): C₂₁H₂₁N · HCl
• Número CAS: 65473-14-5
• Peso molecular: 323.86
• Número MDL: MFCD00059047
• Código UNSPSC: 51102829
• ID de substância PubChem: 329818590
• NACRES: NA.76

Propriedades

• Ensaio: ≥99%
• Nível de qualidade: 200
• Formulário: powder
• solubilidade: ethanol: soluble 50 mg/mL
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria; fungi; yeast
• Modo de ação: cell wall synthesis | interferes; enzyme | inhibits
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• chave InChI: OLUNPKFOFGZHRT-YGCVIUNWSA-N

Descrição

Aplicação

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

Ações bioquímicas/fisiológicas

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable