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M6680

Sigma-Aldrich

Se-(Methyl)selenocysteine hydrochloride

≥95% (TLC)

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About This Item

Fórmula empírica (Notação de Hill):
C4H9NO2Se · HCl
Número CAS:
863394-07-4
Peso molecular:
218.54
Número MDL:
MFCD03412450
Código UNSPSC:
12352209
ID de substância PubChem:
24278564
NACRES:
NA.32

Nível de qualidade

200

Ensaio

≥95% (TLC)

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.C[Se]C[C@H](N)C(O)=O

InChI

1S/C4H9NO2Se.ClH/c1-8-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H/t3-;/m0./s1

chave InChI

JMPVTFHGWJDSDV-DFWYDOINSA-N

Descrição geral

Selenium (Se)-(Methyl) selenocysteine (MeSeCys) is a methylated product of selenocysteine, this reaction is catalyzed by selenocysteine methyltransferase (SMT) in Astragalus bisulcatus.

Aplicação

Se-(Methyl) selenocysteine hydrochloride has been used as a standard in fluorescence-XANES (X-ray absorption near-edge spectroscopy) imaging.

Ações bioquímicas/fisiológicas

Se-(Methyl)selenocysteine is a chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture.
Selenium (Se)-(Methyl) selenocysteine functions as a potent chemotherapeutic agent for human breast cancer. Enhanced production of methlylselenol from L-Se-methylselenocysteine in vivo alters redox status of cells and oxidatively triggers cellular apoptosis. It is implicated in inhibition of mammary tumor formation in rats.

Aplicação

Nº do produto
Descrição
Preços

Palavra indicadora

Danger

Frases de perigo

H301 + H331,H373,H410

Classificações de perigo

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
SLCD8869
SLBX5460
SLBT5501
SLBP0657V
SLBN2066V

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1 of 4

DL-Methionine European Pharmacopoeia (EP) Reference Standard

M0950000

DL-Methionine

Dimethyl selenide ≥99.0% (GC)

Sigma-Aldrich

41572

Dimethyl selenide

Selenourea 98%

Sigma-Aldrich

230499

Selenourea

Sodium selenite 99%

Sigma-Aldrich

214485

Sodium selenite

Dimethyldiselenide and methylseleninic acid generate superoxide in an in vitro chemiluminescence assay in the presence of glutathione: implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine.
Spallholz JE
Nutrition and Cancer, 40(1), 34-41 (2001)
Synchrotron-based X-ray absorption near-edge spectroscopy imaging for laterally resolved speciation of selenium in fresh roots and leaves of wheat and rice.
Wang P
Journal of Experimental Botany, 66(15), 4795-4806 (2015)
Junkun Ma et al.
Biological trace element research, 191(1), 159-166 (2018-12-14)
Mastitis is one of the most important diseases affecting the dairy industry in the world, and it also poses a great threat to human food safety. In this study, we explored whether selenium can inhibit the activation of the NALP3
N V Dolgova et al.
Metallomics : integrated biometal science, 8(3), 305-312 (2016-01-20)
Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been conflicting reports upon human health benefits and detriments arising
Se-methylselenocysteine: a new compound for chemoprevention of breast cancer.
Medina D
Nutrition and Cancer, 40(1), 12-17 (2001)
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Chromatograms

application for HPLC

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