M4937
Anti-Melanocortin-3 Receptor antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Sinônimo(s):
Anti-MC3R
Faça loginpara ver os preços organizacionais e de contrato
About This Item
conjugado:
unconjugated
application:
ARR
WB
WB
clone:
polyclonal
reatividade de espécies:
rat, mouse (predicted)
citations:
8
técnica(s):
microarray: suitable
western blot: 1:2,000 using rat brain homogenate extract
western blot: 1:2,000 using rat brain homogenate extract
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
IgG fraction of antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
antigen 40 kDa
reatividade de espécies
rat, mouse (predicted)
técnica(s)
microarray: suitable
western blot: 1:2,000 using rat brain homogenate extract
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
mouse ... Mc3r(17201)
rat ... Mc3r(29310)
Descrição geral
Melanocortins are regulatory peptides derived from post-translational processing of the larger pro-opiomelanocortin (POMC) precursor. Melanocortin-3 Receptor (MC3-R) is a 360 amino acid containing transmembrane protein that belongs to G-protein coupled receptor family and is expressed mainly in adult central nervous system at high levels in a restricted number of neurons of the hypothalamus and the limbic system.
Imunogênio
A synthetic peptide corresponding to the N-terminal region of rat melanocortin receptor 3 (amino acids 15-33) coupled to keyhole limpet hemocyanin (KLH). This sequence is highly conserved in mouse MC3-R (89% identity).
Aplicação
Anti-Melanocortin-3 Receptor antibody produced in rabbit has been used in western blotting and immunocytochemistry.
Ações bioquímicas/fisiológicas
Melanocortin-3 (MC3) receptor has a crucial role in facilitating the effects of the melanocortin system on energy homeostasis. The MC3 receptor has been proposed to mediate the actions of MSH, in particular those of α-MSH and γ-MSH peptides. MC3-R is thought to regulate fat stores by a metabolic pathway. MC3-R knockout mice (MC3-R-/-) have increased fat mass, but not high body mass index, are hyperleptinaemic and develop mild hyperinsulinaemia. In contrast to MC3-R, MC4-R primarily controls food intake, suggesting that both MC3 and MC4 receptors may play a complementary role in weight control.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Não está encontrando o produto certo?
Experimente o nosso Ferramenta de seleção de produtos.
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Escolha uma das versões mais recentes:
Certificados de análise (COA)
Lot/Batch Number
Não está vendo a versão correta?
Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Mc3 and Mc4 receptors: complementary role in weight control
Raffin S M L, et al.
European Journal of Endocrinology, 144(1), 207-208 (2019)
Paul M Holloway et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(9), 1936-1944 (2015-06-27)
Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin (MC) receptors has previously shown to inhibit leukocyte recruitment in peripheral inflammation, however, it is not known whether treatments
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion
Leoni G, et al.
Faseb Journal, 22(12), 4228-4238 (2008)
A S Chen et al.
Nature genetics, 26(1), 97-102 (2000-09-06)
Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has remained unknown. We evaluated the
Magdalena K Kaneva et al.
British journal of pharmacology, 167(1), 67-79 (2012-04-05)
Melanocortin MC(1) and MC(3 ) receptors, mediate the anti-inflammatory effects of melanocortin peptides. Targeting these receptors could therefore lead to development of novel anti-inflammatory therapeutic agents. We investigated the expression of MC(1) and MC(3) receptors on chondrocytes
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica