M3935

Meloxicam sodium salt hydrate

≥98% (HPLC)

• Sinônimo(s): 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide sodium hydrate, Metacam sodium salt hydrate, Mobec sodium salt hydrate, UH-AC 62XX sodium salt hydrate
• Fórmula empírica (Notação de Hill): C₁₄H₁₂N₃NaO₄S₂ · xH₂O
• Número CAS: 71125-39-8
• Peso molecular: 373.38 (anhydrous basis)
• Número MDL: MFCD11046047
• Código UNSPSC: 51111800
• ID de substância PubChem: 24278802
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: light yellow to dark yellow
• solubilidade: DMSO: 5 mg/mL, clear
• originador: Boehringer Ingelheim
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: O.[Na+].CN1C(C(=O)Nc2ncc(C)s2)=C([O-])c3ccccc3S1(=O)=O
• InChI: 1S/C14H13N3O4S2.Na.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;;/h3-7,18H,1-2H3,(H,15,16,19);;1H2/q;+1;/p-1
• chave InChI: IZBZAOZGNNQKPJ-UHFFFAOYSA-M
• Informações sobre genes: human ... PTGS2(5743)

Descrição

Aplicação

Meloxicam sodium salt hydrate has been used:

• as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor
• as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures
• as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)
• to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein expression in RAW246.7 cells

Ações bioquímicas/fisiológicas

Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID). It is synthesized from piroxicam with aryl and the pyridyl ring substitution. Meloxicam is a cyclooxygenase-2 (COX-2) inhibitor, it may be useful in treating inflammation and pain. Meloxicam has been shown to stop thymulin-induced increas in concentration of cytokines and Nerve growth factor (NGF) in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro. It promotes apoptosis in hepatocellular carcinoma.

Características e benefícios

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301,H315,H319,H335
• Declarações de precaução: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable