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Documentos Principais

M1574

Sigma-Aldrich

Miglitol

Sinônimo(s):

1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

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About This Item

Fórmula empírica (Notação de Hill):
C8H17NO5
Número CAS:
72432-03-2
Peso molecular:
207.22
Número CE:
276-661-6
Código UNSPSC:
12352205
NACRES:
NA.25

fonte biológica

synthetic (organic)

Nível de qualidade

200

Ensaio

≥98% (HPLC)

Formulário

powder

pf

142-147  °C

solubilidade

water: 5 mg/mL, clear, colorless to faintly yellow

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

N1([C@@H]([C@H]([C@@H]([C@H](C1)O)O)O)CO)CCO

InChI

1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1

chave InChI

IBAQFPQHRJAVAV-ULAWRXDQSA-N

Descrição geral

Miglitol is an alpha-glucosidase inhibitor used as a glucose-lowering drug in diabetes research.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
SLCF0480
SLBN6602V
SLBH5083
SLBC4319
SLBB0333

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Kazutaka Aoki et al.
Acta diabetologica, 49(3), 225-230 (2011-09-08)
We recently reported that the administration of miglitol alone just before breakfast improved postprandial hyperglycemia and increased active glucagon-like peptide-1 (GLP-1) levels after lunch in men without diabetes. Miglitol and dipeptidyl peptidase-4 inhibitors, such as sitagliptin, enhance plasma active GLP-1
Takuo Emoto et al.
The American journal of cardiology, 109(1), 42-46 (2011-09-29)
Repeated postprandial hyperglycemia may play an important role in the development of atherosclerosis by suppressing vascular endothelial function. Although miglitol suppresses the elevation of blood glucose levels shortly after a meal more than other α-glucosidase inhibitors, the effect of 3-month
Kyra Jones et al.
Bioorganic & medicinal chemistry, 19(13), 3929-3934 (2011-06-15)
Inhibition of intestinal α-glucosidases and pancreatic α-amylases is an approach to controlling blood glucose and serum insulin levels in individuals with Type II diabetes. The two human intestinal glucosidases are maltase-glucoamylase and sucrase-isomaltase. Each incorporates two family 31 glycoside hydrolases
Kenichi Matsuura et al.
Diabetes technology & therapeutics, 14(5), 423-429 (2012-02-10)
We compared the effects of miglitol as an add-on to bolus insulin and dose-intensified bolus insulin on postprandial glycemic excursions by continuous glucose monitoring (CGM). The glucose levels of 21 type 2 diabetes patients admitted for glycemic control were monitored
Hongxiang Hui et al.
Chinese medicine, 4, 11-11 (2009-06-16)
Conventional drugs treat diabetes by improving insulin sensitivity, increasing insulin production and/or decreasing the amount of glucose in blood. Several herbal preparations are used to treat diabetes, but their reported hypoglycemic effects are complex or even paradoxical in some cases.
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