M024080

ssH-Linker

configured for PerkinElmer, configured for Polygen

• Sinônimo(s): 9,11-Dioxa-2-aza-10-phosphatridecanoic acid, 10-[bis(1-methylethyl)amino]-13-cyano-, 2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl este
• Fórmula empírica (Notação de Hill): C₃₈H₅₃N₄O₅P
• Peso molecular: 676.83
• Número MDL: MFCD12912425
• Código UNSPSC: 12352200
• ID de substância PubChem: 329817759
• NACRES: NA.51

Propriedades

• tipo: for DNA synthesis
• Nível de qualidade: 200
• linha de produto: Proligo Reagents
• Ensaio: ≥98% (³¹P-NMR); ≥98.0% (reversed phase HPLC)
• compatibilidade: configured for PerkinElmer; configured for Polygen
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: COc1ccc(cc1)C(NCCOC(=O)NCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c3ccccc3
• InChI: 1S/C38H53N4O5P/c1-31(2)42(32(3)4)48(47-29-16-25-39)46-28-15-7-6-14-26-40-37(43)45-30-27-41-38(33-17-10-8-11-18-33,34-19-12-9-13-20-34)35-21-23-36(44-5)24-22-35/h8-13,17-24,31-32,41H,6-7,14-16,26-30H2,1-5H3,(H,40,43)
• chave InChI: VTFLXOVDKJUHER-UHFFFAOYSA-N

Descrição

Descrição geral

ssH-linker comprises an internal carbamate group attached to the MMT-protected amino group via a short spacer. The carbamate moiety facilitates the cleavage of the MMT group under mildly acidic conditions while increasing the stability of the MMT group during the deprotection of the oligonucleotide with ammonia. The carbamate group also enhances the reactivity of the amino group through a neighbor group effect, and thereby accelerates conjugations to amino reactive modifiers and reporters. The MMT-group of ssH-linker serves as an excellent purification handle after the oligonucleotide synthesis in trityl-on mode, similar to the DMT-group of conventional oligonucleotides. The MMT-group is cleaved under very mild conditions in aqueous acetic acid (10% glacial acetic acid in the water, 20 min. room temp.) Alternatively, the MMT-group can be cleaved on the synthesis instrument with an acidic deblock solution to enable on-support labeling protocols.

Informações legais

This product is covered under US Patent Number 7,491,857

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable