A111000

DMT-dA(bz) Phosphoramidite

• Sinônimo(s): DMT-dA(bz) Amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyadenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
• Fórmula empírica (Notação de Hill): C₄₇H₅₂N₇O₇P
• Número CAS: 98796-53-3
• Peso molecular: 857.93
• Número MDL: MFCD00036314
• Código UNSPSC: 41116107
• ID de substância PubChem: 329770657
• NACRES: NA.51

Propriedades

• fonte biológica: non-animal source (no BSE/TSE risk)
• Nível de qualidade: 200
• tipo: for DNA synthesis
• linha de produto: Proligo Reagents
• Ensaio: ≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• forma: powder or granules
• técnica(s): oligo synthesis: suitable
• Impurezas: ≤0.3 wt. % water content (Karl Fischer)
• cor: white to off-white
• λ: conforms (UV/VIS Identity)
• perfil de nucleosídeo: base: deoxyadenosine; base protecting group: benzoyl; 2' protecting group: none; 5' protecting group: DMT; deprotection: standard
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
• InChI: 1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1
• chave InChI: GGDNKEQZFSTIMJ-AKWFTNRHSA-N

Descrição

Descrição geral

DMT-dA(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites.

Its key features include:

• Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides
• The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides