K0133

Kaempferol

≥90% (HPLC), powder

• Sinônimo(s): 3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
• Fórmula empírica (Notação de Hill): C₁₅H₁₀O₆
• Número CAS: 520-18-3
• Peso molecular: 286.24
• Beilstein: 304401
• Número MDL: MFCD00016938
• Código UNSPSC: 12191503
• ID de substância PubChem: 24896195
• NACRES: NA.25

Propriedades

• fonte biológica: synthetic
• Nível de qualidade: 100
• Ensaio: ≥90% (HPLC)
• forma: powder
• condição de armazenamento: protect from light
• cor: yellow
• pf: 277 °C
• solubilidade: ethanol: 20 mg/mL; DMSO: 50 mg/mL
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: Oc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
• chave InChI: IYRMWMYZSQPJKC-UHFFFAOYSA-N
• Informações sobre genes: human ... CDC2(983) , CDK5(1020) , CDK6(1021) , CYP1A2(1544) , CYP2C9(1559) , GSK3A(2931) ; mouse ... Hexa(15211)

Descrição

Descrição geral

Kaempferol is a natural dietary flavonoid and a polyphenol antioxidant found in various fruits and vegetables. Kaempferol is present in plants in a different glycosidic form such as astragalin by binding with different sugars.

Aplicação

Kaempferol (KAE) has been used:

• to check its potential effect as an antioxidant and neuroprotective agent against rotenone-induced Parkinson′s disease (PD) model in SH-S5Y5 cells
• to test its anti-inflammatory effect on lipopolysaccharide (LPS)-induced inflammatory injury in human aortic endothelial cells (HAECs)
• to study its apoptosis sensitizing effect on non-small cell lung cancer (NSCLC) cells by inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2)

Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.

Ações bioquímicas/fisiológicas

Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.

The diphenylpropane component of Kaempferol contributes to its hydrophobic properties. It has shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Kaempferol induces significant nuclear DNA degradation concurrent with lipid peroxidation. It also inhibits topoisomerase I catalyzed DNA religation. Kaempferol may also inhibit the activity of fatty acid synthase.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges