282200

Galangin

autophagy inducing flavonoid

• Sinônimo(s): 3,5,7-Trihydroxyflavone, Norizalpinin
• Fórmula empírica (Notação de Hill): C₁₅H₁₀O₅
• Número CAS: 548-83-4
• Peso molecular: 270.24
• Beilstein: 272179
• Número CE: 208-960-4
• Número MDL: MFCD00006833
• Código UNSPSC: 41116107
• ID de substância PubChem: 57648294
• NACRES: NA.79

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: powder
• cor: yellow
• pf: 214-215 °C (lit.)
• cadeia de caracteres SMILES: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
• chave InChI: VCCRNZQBSJXYJD-UHFFFAOYSA-N
• Informações sobre genes: human ... ADORA2A(135) , ADORA3(140) , CYP1A2(1544) ; rat ... Adora1(29290) , Adora2a(25369)

Descrição

Descrição geral

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

Aplicação

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

Ações bioquímicas/fisiológicas

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves