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I2512

Sigma-Aldrich

Sodium iodoacetate

powder, ≥98%

Sinônimo(s):

Iodoacetic acid sodium salt

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About This Item

Fórmula linear:
ICH2COONa
Número CAS:
305-53-3
Peso molecular:
207.93
Beilstein:
4009322
Número CE:
206-165-7
Número MDL:
MFCD00002686
Código UNSPSC:
12352202
ID de substância PubChem:
24895977
NACRES:
NA.77

product name

Sodium iodoacetate, ≥98%

fonte biológica

synthetic (organic)

Ensaio

≥98%

forma

powder

pf

208 °C (dec.) (lit.)

solubilidade

H2O: 100 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Na+].[O-]C(=O)CI

InChI

1S/C2H3IO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1

chave InChI

AGDSCTQQXMDDCV-UHFFFAOYSA-M

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Aplicação

Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains.
Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.

Ações bioquímicas/fisiológicas

Used to induce osteoarthritis-like lesions and functional impairment in rats, for testing of chondroprotective agents and diagnostic imaging techniques.

Pictogramas

Skull and crossbonesCorrosion
GHS06,GHS05

Palavra indicadora

Danger

Frases de perigo

H301,H314

Classificações de perigo

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

406.4 °F

Ponto de fulgor (°C)

208 °C

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Iodoacetamida ≥99% (NMR), crystalline

Sigma-Aldrich

I6125

Iodoacetamida

Iodoacetic anhydride

Sigma-Aldrich

284262

Iodoacetic anhydride

Iodoacetic acid N-hydroxysuccinimide ester powder

Sigma-Aldrich

I9760

Iodoacetic acid N-hydroxysuccinimide ester

C Guingamp et al.
Arthritis and rheumatism, 40(9), 1670-1679 (1997-10-27)
To characterize the dose-responsiveness of morphologic and biochemical chondral changes relative to mobility in mono-iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Rat mobility was assessed by biotelemetry. Articular lesions were characterized by macroscopic and histologic examinations. Cartilage proteoglycan metabolism was evaluated
Roberto E Guzman et al.
Toxicologic pathology, 31(6), 619-624 (2003-10-31)
Osteoarthritis (OA) is a degenerative joint disease characterized by joint pain and a progressive loss of articular cartilage. Studies to elucidate the pathophysiology of OA have been hampered by the lack of a rapid, reproducible animal model that mimics both
Matilde Tschon et al.
Cells, 9(7) (2020-07-02)
The purpose of this study was to verify the efficacy of a single intra-articular (i.a.) injection of a hyaluronic acid-chitlac (HY-CTL) enriched with two low dosages of triamcinolone acetonide (TA, 2.0 mg/mL and 4.5 mg/mL), in comparison with HY-CTL alone
Ikufumi Takahashi et al.
PloS one, 13(4), e0196625-e0196625 (2018-04-27)
This study aimed to investigate the histopathological changes in the patellofemoral joint using a rat model of osteoarthritis that was induced using monosodium iodoacetate, and to establish a novel model of patellofemoral osteoarthritis in a rat model using histopathological analysis.
Hyung Jin Lim et al.
Food science & nutrition, 8(12), 6550-6556 (2020-12-15)
In Asia, Vigna angularis (azuki bean) has been used as a traditional medicine to treat various diseases because of its biological properties. Osteoarthritis (OA) and osteoporosis (OP) are common regenerative bone diseases that are characterized by deterioration of joint and
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