I1286

Icariin

≥94% (HPLC)

• Sinônimo(s): 4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside
• Fórmula empírica (Notação de Hill): C₃₃H₄₀O₁₅
• Número CAS: 489-32-7
• Peso molecular: 676.66
• Número MDL: MFCD00210516
• Código UNSPSC: 12352205
• ID de substância PubChem: 329815347
• NACRES: NA.25

Propriedades

• Ensaio: ≥94% (HPLC)
• cor: light yellow to yellow
• solubilidade: DMSO: 50 mg/mL, clear, colorless to dark yellow
• aplicação(ões): metabolomics; vitamins, nutraceuticals, and natural products
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2
• InChI: 1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
• chave InChI: TZJALUIVHRYQQB-XLRXWWTNSA-N

Descrição

Descrição geral

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.

Aplicação

Icariin has been used:

• in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats
• to test its analgesic effects on lower back pain (LBP) in rats
• as a potential treatment in osteoporosis condition in rats
• to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes
• as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells

Ações bioquímicas/fisiológicas

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.

Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable