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I0157

Sigma-Aldrich

Ibudilast

≥99% (HPLC), solid

Sinônimo(s):

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404

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About This Item

Fórmula empírica (Notação de Hill):
C14 H18 N2 O
Número CAS:
50847-11-5
Peso molecular:
230.31
Número MDL:
MFCD00864808
Código UNSPSC:
41106305
ID de substância PubChem:
24278482
NACRES:
NA.77

Ensaio

≥99% (HPLC)

Formulário

solid

cor

white

solubilidade

DMSO: soluble 28 mg/mL
H2O: soluble 4.5 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C)C(=O)c1c(nn2ccccc12)C(C)C

InChI

1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

chave InChI

ZJVFLBOZORBYFE-UHFFFAOYSA-N

Informações sobre genes

human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

Ações bioquímicas/fisiológicas

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319,H335

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BGBC1725
108K37901
108K37902
108K37903
097K3789

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Kenji Yagi et al.
Neurosurgery, 66(3), 551-559 (2010-02-04)
Phosphodiesterase-4 (PDE-4) is a cyclic adenosine monophosphate-specific enzyme involved in various inflammatory diseases. We studied its role in and the effect of ibudilast, which predominantly blocks PDE-4, on rat cerebral aneurysms. Cerebral aneurysms were induced at the anterior cerebral artery-olfactory
Sarah E Snider et al.
European journal of pharmacology, 679(1-3), 75-80 (2012-02-07)
Over 800,000 Americans abuse the psychomotor stimulant, methamphetamine, yet its abuse is without an approved medication. Methamphetamine induces hypermotor activity, and sensitization to this effect is suggested to represent aspects of the addiction process. Methamphetamine's regulation of 3'-5'-cyclic adenosine monophosphate
Keiko Sakuma et al.
Eye & contact lens, 35(5), 251-254 (2009-08-13)
To assess the influence of topical application of ibudilast for seasonal allergic conjunctivitis in patients wearing soft contact lenses (SCLs). There were 16 SCL wearers (32 eyes) with allergic conjunctivitis due to cedar pollen, who were studied from February to
Jaclyn M Schwarz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 961-971 (2013-01-18)
Adolescence in humans represents a unique developmental time point associated with increased risk-taking behavior and experimentation with drugs of abuse. We hypothesized that exposure to drugs of abuse during adolescence may increase the risk of addiction in adulthood. To test
P Rolan et al.
Expert opinion on pharmacotherapy, 10(17), 2897-2904 (2009-11-26)
Ibudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for almost 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS
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Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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