H7541
IL-10 human
HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture
Sinônimo(s):
IL-10
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About This Item
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product name
Interleukin-10 human, IL-10, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
fonte biológica
human
Nível de qualidade
recombinante
expressed in HEK 293 cells
Ensaio
≥95% (SDS-PAGE)
forma
lyophilized powder
potência
≤1.5 ng/mL EC50
qualidade
endotoxin tested
peso molecular
dimer 17 kDa (glycosylated)
técnica(s)
cell culture | mammalian: suitable
Impurezas
≤1EU/mg
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... IL10(3586)
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Descrição geral
Interleukin-10 gene with five exons is mapped to human chromosome 1. The gene codes for 35 kD protein containing 178 amino acids. IL-10 is a homodimer with two, non-covalently bonded monomers.
Aplicação
Interleukin-10 human has been used to study its effect on activation of endogenous signal transducer and activator of transcription 1 (STAT1)/STAT3 in the knock-in, in A549 human lung adenocarcinoma cell line.
Ações bioquímicas/fisiológicas
IL-10 is an important regulator of the functions of lymphoid and myeloid cells. IL-10 can block the activation of cytokine synthesis and several accessory functions of macrophages. Human and mouse IL-10 share a 73% sequence homology. However, human IL-10 acts on both human and mouse target cells, while mouse IL-10 has species-specific activity. In mouse, the cellular sources of IL-10 consist of Th2 cells, activated fetal thymocytes, macrophages, keratinocytes, LY-1+ (CD5+), and normal B cells. In human, the cellular sources of IL-10 consist of CD4+ T cells and T cell clones, thymocytes, B cells, B cell lymphomas, macrophages, mast cell lines and keratinocytes. IL-10 stimulates the growth of stem cells, mast cells and thymocytes. IL-10 enhances cytotoxic T cell development, and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing the cell-type dependent expression of either angiogenic or angiostatic factors.
Interleukin-10 regulates lymphoid and myeloid cell functions. It blocks the activation of cytokine synthesis and several accessory functions of macrophages. IL-10 enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing cell-type dependent expression of either angiogenic or angiostatic factors.
forma física
Lyophilized from a 0.2 μm filtered solution of 10mM Tris-HCl pH 7.4 + 150mM NaCl
Nota de preparo
HumanKine Interleukin-10 (IL-10) is expressed in human HEK 293 cells as a glycosylated, non-disulfide linked homodimer with an apparent molecular mass of 17 kDa due to glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Nota de análise
The specific activity was determined by the dose-dependent stimulation of the proliferation of MC/9 cells (mouse master cell line) in presence of 200 pg/mL IL-4.
Informações legais
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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