GW20031F
Anti-Leptin antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
Produtos recomendados
fonte biológica
chicken
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
rat, mouse, human
fabricante/nome comercial
Genway 15-288-20031F
técnica(s)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... LEP(3952)
Aplicação
Anti-Leptin antibody produced in chicken has been used for the immunohistochemistry study of mouse embryo and ovum. It is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.
Ações bioquímicas/fisiológicas
LEP (leptin) encoded protein plays a key role in the regulation of body weight. It is secreted by white adipocytes. It has a key role in regulating the signaling pathway that can inhibit food intake and/or control energy expenditure to maintain constancy of the adipose mass. It is also involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Defects in this gene can cause a rare disease characterized by low levels of serum leptin, severe hyperphagia and severe obesity, and morbid obesity with hypogonadism.
forma física
Solution in phosphate buffered saline containing 0.02% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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F F Chehab
Trends in pharmacological sciences, 21(8), 309-314 (2000-08-05)
Leptin, an adipocyte-derived hormone, informs neuroendocrine pathways about the status of energy stores in adipose tissue. The integration of this peripheral signal in hypothalamic networks results in activation of peripheral metabolic pathways that control energy build-up and expenditure. Firing of
Laura C Schulz et al.
Reproduction (Cambridge, England), 141(6), 767-777 (2011-03-30)
The hormone leptin, which is primarily produced by adipose tissue, is a critical permissive factor for multiple reproductive events in the mouse, including implantation. In the CD1 strain, maternally derived leptin from the oocyte becomes differentially distributed among the blastomeres
N Patel et al.
The Journal of biological chemistry, 274(32), 22729-22738 (1999-07-31)
We report the expression cloning of a novel leptin-binding protein of the immunoglobulin superfamily (OB-BP1) and a cross-hybridizing clone (OB-BP2) that is identical to a recently described sialic acid-binding I-type lectin called Siglec-5. Comparisons to other known Siglec family members
A leptin missense mutation associated with hypogonadism and morbid obesity.
A Strobel et al.
Nature genetics, 18(3), 213-215 (1998-03-21)
G M Lord et al.
Nature, 394(6696), 897-901 (1998-09-11)
Nutritional deprivation suppresses immune function. The cloning of the obese gene and identification of its protein product leptin has provided fundamental insight into the hypothalamic regulation of body weight. Circulating levels of this adipocyte-derived hormone are proportional to fat mass
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