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G110

Sigma-Aldrich

Guanabenz acetate salt

powder

Sinônimo(s):

1-(2,6-Dichlorobenzylideneamino)guanidine acetate salt, WY-8678

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About This Item

Fórmula empírica (Notação de Hill):
C8H8Cl2N4 · C2H4O2
Número CAS:
23256-50-0
Peso molecular:
291.13
Número CE:
245-534-7
Número MDL:
MFCD00153801
Código UNSPSC:
12352200
ID de substância PubChem:
24277775
NACRES:
NA.77

Formulário

powder

Nível de qualidade

200

cor

white

solubilidade

H2O: 10 mg/mL
alcohol: 50 mg/mL

originador

Wyeth

cadeia de caracteres SMILES

CC(O)=O.NC(=N)N\N=C\c1c(Cl)cccc1Cl

InChI

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

chave InChI

MCSPBPXATWBACD-GAYQJXMFSA-N

Informações sobre genes

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Ações bioquímicas/fisiológicas

Centrally acting α2 adrenoceptor agonist; I2 imidazoline binding site ligand; antihypertensive.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the α2-Adrenoceptors and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P301 + P310

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
SLCH9037
SLCF2839
SLCB5424
SLBV3530
SLBP0651V

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Phenazine 98%

Sigma-Aldrich

P13207

Phenazine

Aminoguanidine hydrochloride ≥98%

Sigma-Aldrich

396494

Aminoguanidine hydrochloride

Fabienne Gug et al.
Bioconjugate chemistry, 21(2), 279-288 (2010-01-23)
The synthesis of affinity matrices for 6-aminophenanthridine (6AP) and 2,6-dichlorobenzylidenaminoguanidine (Guanabenz, GA), two unrelated prion inhibitors, is described. In both cases, the same simple spacer, epsilon-aminocaproylaminopentanol, was introduced by a Mitsunobu reaction and the choice of the anchoring position of
Pavel Tsaytler et al.
Science (New York, N.Y.), 332(6025), 91-94 (2011-03-10)
Many biological processes are regulated through the selective dephosphorylation of proteins. Protein serine-threonine phosphatases are assembled from catalytic subunits bound to diverse regulatory subunits that provide substrate specificity and subcellular localization. We describe a small molecule, guanabenz, that bound to
Pavel Tsaytler et al.
The FEBS journal, 280(2), 766-770 (2012-02-22)
Selective and reversible phosphorylation is one of the most common post-translational modifications of proteins. Although kinase inhibitors are popular in drug development programmes, selective pharmacological manipulation of phosphatase activity has been challenging to achieve. We review recent advances in the
Cécile Voisset et al.
Biotechnology journal, 6(6), 668-673 (2011-05-14)
In addition to its involvement in protein synthesis, the ribosome is implicated in protein folding. Some co-translational events, such as the rhythm of protein synthesis, the passage through the exit tunnel of the ribosome, or the interaction with ribosome-associated chaperones
Melissa J Fullwood et al.
Progress in molecular biology and translational science, 106, 75-106 (2012-02-22)
The unfolded protein response, also known as endoplasmic reticulum (ER) stress, has been implicated in numerous human diseases, including atherosclerosis, cancer, diabetes, and neurodegenerative disorders. Protein misfolding activates one or more of the three ER transmembrane sensors to initiate a
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