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G0295

Sigma-Aldrich

Anti-GABAA Receptor (α6 subunit), Cytosolic Loop antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Sinônimo(s):

Anti-γ-Aminobutyric Acid Type A Receptor (α6 subunit)

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About This Item

Número MDL:
MFCD07370321
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous glycerol solution

uso

sufficient for 10 blots

reatividade de espécies

rat

técnica(s)

western blot: 1:1000 using rat brain membrane fraction.

nº de adesão UniProt

P30191

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

rat ... Gabra6(29708)

Descrição geral

γ -aminobutyric acid (GABA) receptor is the multifunctional, pentameric membrane proteins that operate GABA-gated chloride channels. It acts as major inhibitory neurotransmitter in the adult mammalian brain. It is the members of the neurotransmitter ligand-gated ion channels which plays various functions in the central nervous system, the peripheral nervous system, and in some nonneuronal tissues. At least four types of subunits (α, β, γ and δ) of GABA have been identified. Generally it contains one type of α and β subunit, and a single γ polypeptide in a ratio of 2:2:1.

Imunogênio

fusion protein with the amino acid sequence representing the cytosolic loop of the rat GABAA receptor (α6 subunit)

Aplicação

Anti-GABAA Receptor (α6 subunit), cytosolic loop antibody is suitable for western blot at a dilution of 1:1,000 using rat brain membrane fraction.

Ações bioquímicas/fisiológicas

GABA is synthesized primarily from glutamate by glutamate decarboxylase (GAD). It is triggered by binding to its ligand-gated chloride channels, GABA(A) and GABA(C) as well as metabotropic receptor GABA(B). Along with neural development, it is also involved in a wide variety of physiological functions in tissues and organs outside the brain.

Descrição-alvo

Detects 56-57 kDa GABAA receptor α6 subunit in rat brain membrane fractions.

forma física

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Andrea Giovannucci et al.
Nature neuroscience, 20(5), 727-734 (2017-03-21)
Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown. Here we show, using two-photon microscopy to track neural activity over multiple days
U Rudolph et al.
Trends in pharmacological sciences, 22(4), 188-194 (2001-04-03)
The enhancement of GABA-mediated synaptic transmission underlies the pharmacotherapy of various neurological and psychiatric disorders. GABA(A) receptors are pluripotent drug targets that display an extraordinary structural heterogeneity: they are assembled from a repertoire of at least 18 subunits (alpha1-6, beta1-3
Richard W Olsen et al.
Neuropharmacology, 56(1), 141-148 (2008-09-02)
This mini-review attempts to update experimental evidence on the existence of GABA(A) receptor pharmacological subtypes and to produce a list of those native receptors that exist. GABA(A) receptors are chloride channels that mediate inhibitory neurotransmission. They are members of the
Structure and pharmacology of vertebrate GABAA receptor subtypes.
P J Whiting et al.
International review of neurobiology, 38, 95-138 (1995-01-01)
Masahito Watanabe et al.
International review of cytology, 213, 1-47 (2002-02-12)
Gamma-aminobutyrate (GABA) is a major inhibitory neurotransmitter in the adult mammalian brain. GABA is also considered to be a multifunctional molecule that has different situational functions in the central nervous system, the peripheral nervous system, and in some nonneuronal tissues.
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