G5544
Anti-GABAA Receptor (α6 subunit) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinônimo(s):
Anti-γ-Aminobutyric Acid Type A Receptor (α6 subunit), Anti-GABRA6
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About This Item
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
lyophilized powder
reatividade de espécies
rat
técnica(s)
western blot: 1:200 using rat brain membranes
nº de adesão UniProt
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... GABRA6(2559)
mouse ... Gabra6(14399)
rat ... Gabra6(29708)
Descrição geral
GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.
Imunogênio
peptide corresponding to amino acids 20-37 of rat GABA(A) α6. This sequence is identical in mouse and shares 17 of 19 residues in human.
Aplicação
Anti-GABAA Receptor (α 6 subunit) antibody produced in rabbit is suitable for the immunofluorescent detection of GABAA receptor α 6 in cerebella of mice. It is suitable for immunoblotting at a working dilution of 1:200 using rat brain membranes.
Ações bioquímicas/fisiológicas
The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. Mutations in the gene may be responsible for the pathogenesis of childhood absence epilepsy (CAE). Polymorphism in this gene is also related to attenuation in hormonal and blood pressure responses under certain psychological stress.
Descrição-alvo
Anti-GABA(A) Receptor (α6 subunit) specifically recognizes the GABA(A) receptor α6 subunit protein and may be used for the detection of the GABA(A) receptor α6 subunit protein. The inhibitory neurotransmitter GABA (α-aminobutyricacid
forma física
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Joanne Falck et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(14), 2943-2959 (2020-03-04)
Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric disorders as well as Pontocerebellar Hypoplasia type 3 (PCH3). We
Ciria C Hernandez et al.
The Journal of physiology, 589(Pt 23), 5857-5878 (2011-09-21)
A GABA(A) receptor α6 subunit mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy (CAE), but the molecular basis for alteration of GABA(A) receptor function is unclear. The R46W mutation is
X Li et al.
Neuroscience, 152(2), 391-406 (2008-02-26)
The cerebellar cortex of protein O-mannose UDP-N-acetylglucosaminyl transferase 1 (POMGnT1) knockout mice contains discrete clusters of granule neurons that fail to migrate from the external germinal layer (EGL) to the internal granule cell layer (IGL). To test the hypothesis that
Fabian M P Kaiser et al.
The Journal of experimental medicine, 219(9) (2022-08-11)
The genetic causes of primary antibody deficiencies and autism spectrum disorder (ASD) are largely unknown. Here, we report a patient with hypogammaglobulinemia and ASD who carries biallelic mutations in the transcription factor PAX5. A patient-specific Pax5 mutant mouse revealed an
M Uhart et al.
Molecular psychiatry, 9(11), 998-1006 (2004-06-16)
The glucocorticoid component of the stress response has been the subject of intense scientific scrutiny because of the wide ranging pathological consequences resulting from excess glucocorticoid exposure, including mood and anxiety disorders, and cognitive impairment. Exposure to stress activates the
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