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F2379

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Fetuin from fetal bovine serum

lyophilized powder, suitable for cell culture

Sinônimo(s):

Fetuin from fetal calf serum

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About This Item

Número CAS:
9014-81-7
Número CE:
232-762-7
Número MDL:
MFCD00131055
Código UNSPSC:
12352202
NACRES:
NA.61

fonte biológica

bovine serum (fetal)

Nível de qualidade

200

Formulário

lyophilized powder

técnica(s)

cell culture | mammalian: suitable

Impurezas

≤0.3% free N-acetylneuraminic acid

solubilidade

H2O: 1 mg/mL, colorless to faint yellow or tan

nº de adesão UniProt

Q58D62

temperatura de armazenamento

2-8°C

Informações sobre genes

bovine ... FETUB(504615)

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Descrição geral

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Aplicação

Fetuin from fetal bovine serum has been used:
  • to synthesize primary and secondary calciprotein particles (CPP)
  • to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
  • as a supplement in Ham′s F10 media for myoblast culture.

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.

Ações bioquímicas/fisiológicas

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.

Nota de preparo

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
SLCD7337
SLBV0393
SLBS1011V
SLBS1034V

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The present report describes a method for the quantification of N-acetyl- and N-glycolylneuraminic acids without any derivatization, using their (13)C(3)-isotopologues as internal standards and a C(18) reversed-phase column modified by decylboronic acid which allows for the first time a complete
Cellular clearance and biological activity of calciprotein particles depend on their maturation state and crystallinity
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American journal of physiology. Lung cellular and molecular physiology, 298(1), L79-L88 (2009-10-20)
Collectins are collagenous lectins present in blood, respiratory lining fluid, and other mucosal secretions that play important roles in innate defense against infection. The collectin, surfactant protein D (SP-D), limits infection by viruses and bacteria in the respiratory tract, eye
Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature
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Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 159(3), 352-359 (2015)
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