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Documentos Principais

D8821

Sigma-Aldrich

Dextrana

average mol wt 60,000-76,000

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About This Item

Fórmula linear:
(C6H10O5)n
Número CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352201
NACRES:
NA.25

fonte biológica

bacterial (Leuconostoc mesenteroides)

Nível de qualidade

Formulário

powder

atividade óptica

[α]20/D 190 to 201 °, c = 2% (w/v) in water

peso molecular

average mol wt 60,000-76,000

cor

white to off-white

pf

483  °C ((901 °F ))

solubilidade

water: 100 mg/mL at 25 °C, colorless to faintly yellow

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O1C(C(C(C(C1CO)O)O)O)OCC2OC(C(C(C2O)O)O)OCC(O)C(O)C(O)C(O)C=O

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

chave InChI

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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Descrição geral

Dextran is an extracellular bacterial polymer of D-glucopyranose. It consists of α-(1→6) linkage in the main chain with a variable amount of α-(1→2), α-(1→3), α-(1→4) branched linkages. Dextran from L. mesenteroides B512F comprises 95% of α- (1→6) linkages and 5% of α-(1→3) branch linkages. Insoluble dextran from L. mesenteroides 1299 contains 63% α-(1→6), 27% of α-(1→2) and 8% of α-(1→3) linkages.

Aplicação

O uso de dextranas como braços espaçadores longos e hidrofílicos melhora o desempenho das proteínas imobilizadas que agem sobre macromoléculas.
Dextran from Leuconostoc mesenteroides has been used:
  • in resuspension of pellets and in Hanks′ balanced salt solution (HBSS) for the isolation of vascular nuclei from frozen post-mortem brain tissue
  • to prepare dextran solution in phosphate buffer saline and to maintain corneal hydration and restore corneal thickness to physiological levels of human eyes
  • as a polymer solution in the in situ aqueous two-phase systems (ATPS) formation with lysozyme PEGylation reaction

Ações bioquímicas/fisiológicas

Dextran is commercially available as a drug, especially as a blood plasma volume expander. This bacterial polysaccharide has several applications, such as adjuvant, emulsifier, carrier, and stabilizer in the food, pharmaceutical, and chemical industries. Dextran is used in the thickening of jam and ice cream in the food industry. It prevents sugar crystallization and retains moisture. This helps in preserving the flavor and appearance of several food items.

Outras notas

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2


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Dextrana average mol wt 9,000-11,000

Sigma-Aldrich

D9260

Dextrana

Dextrana Mr ~200,000

Sigma-Aldrich

31398

Dextrana

Dextran Mr 450,000-650,000

Sigma-Aldrich

31392

Dextran

Zhiyang Li et al.
Journal of biomedical nanotechnology, 9(11), 1945-1949 (2013-09-26)
For reducing the steric hindrance and nonspecific binding of the target DNA, the dextran was used as molecular arms to be immobilized on the surface of magnetic nanoparticles (MNPs). Magnetic separation was used in preparation of dextran-MNPs (DMNPs). Aspartic acid
Yang Yang et al.
Biochimica et biophysica acta, 1840(1), 288-293 (2013-10-01)
Abnormal adhesion of red blood cells (RBCs) to vascular endothelium is often associated with reduced levels of sialic acids on RBC membranes and with elevated levels of pro-adhesive plasma proteins. However, the synergistic effects of these two factors on the
Elizabeth M Bradshaw et al.
Nature neuroscience, 16(7), 848-850 (2013-05-28)
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young
Hideto Katsuta et al.
Investigative ophthalmology & visual science, 54(6), 4102-4108 (2013-05-23)
To elucidate the role of signals mediated by EphB4 receptor tyrosine kinase and its transmembrane ephrinB2 ligand in corneal lymphatic capillaries. To detect expression of ephrinB2 and EphB4 in mouse corneas, immunohistochemistry of flat-mount corneas from 6- to 10-week-old wild-type
Marisa A Gallicchio et al.
Biochimica et biophysica acta, 1833(12), 2922-2932 (2013-06-12)
Chronic hyperglycaemia during diabetes leads to non-enzymatic glycation of proteins to form advanced glycation end products (AGEs) that contribute to nephropathy. We describe AGE uptake in LLC-PK1 and HK2 proximal tubule cell lines by macropinocytosis, a non-specific, endocytic mechanism. AGE-BSA

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