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D0629

Sigma-Aldrich

3,5-Diiodo-L-thyronine

thyroid hormone analog

Sinônimo(s):

3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine, 3,5-T2, O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine

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About This Item

Fórmula empírica (Notação de Hill):
C15H13I2NO4
Número CAS:
1041-01-6
Peso molecular:
525.08
Beilstein:
2707891
Número CE:
213-867-7
Número MDL:
MFCD00064987
Código UNSPSC:
41116107
ID de substância PubChem:
24893248
NACRES:
NA.26

Ensaio

≥99% (HPLC)

forma

powder

técnica(s)

ligand binding assay: suitable

cor

white to off-white

pf

255 °C

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

N[C@@H](Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1)C(O)=O

InChI

1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)/t13-/m0/s1

chave InChI

ZHSOTLOTTDYIIK-ZDUSSCGKSA-N

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Categorias relacionadas

Ações bioquímicas/fisiológicas

3,5-Diiodo-L-thyronine ((T(2)) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.

Frases de perigo

H412

Declarações de precaução

P273 - P501

Classificações de perigo

Aquatic Chronic 3

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

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3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

T-075

3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution

3,3′,5′-Triiodothyronine-(diiodophenyl-13C6) hydrochloride 99 atom % 13C, 95% (CP)

Sigma-Aldrich

709719

3,3′,5′-Triiodothyronine-(diiodophenyl-13C6) hydrochloride

T1AM ≥98% (HPLC)

Sigma-Aldrich

SML1924

T1AM

L-Thyroxine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

T1775

L-Thyroxine

Maria Moreno et al.
Thyroid : official journal of the American Thyroid Association, 18(2), 239-253 (2008-02-19)
The processes and pathways mediating the intermediary metabolism of carbohydrates, lipids, and proteins are all affected by thyroid hormones (THs) in almost all tissues. Particular attention has been devoted by scientists to the effects of THs on lipid metabolism. Among
C J Huang et al.
Journal of molecular and cellular cardiology, 31(4), 881-893 (1999-05-18)
We previously reported that T3(3,3',5-triiodo-L-thyronine) acutely increases sodium currents (INa) in neonatal rat myocytes. Here we compare the effects of several thyroid hormone analogs, including T4(3,3',5,5'-tetraiodo-L-thyronine), rT3(3,3',5'-triiodo-L-thyronine), D-T3(3,3',5-triiodo-D-thyronine), 3,5-T2(3,5-diiodo-L-thyronine), DIT (3,5-diiodo-L-tyrosine), MIT (3-monoiodo-L-tyrosine), tetrac (3,3',5,5'-tetraiodo-thyroacetic acid), triac (3, 3',5-triiodo-thyroacetic acid)
Anna M Giudetti et al.
Endocrinology, 146(9), 3959-3966 (2005-06-04)
Short-term effects of 3,5-l-diiodothyronine (T2) on lipid biosynthesis were studied in cultured hepatocytes from hypothyroid rats. A comparison with the effects of T3 was routinely carried out. After T2 addition to cell cultures, a distinct stimulation of fatty acid and
Maria Moreno et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(10), 3312-3324 (2011-06-15)
The worldwide prevalence of obesity-associated pathologies, including type 2 diabetes, requires thorough investigation of mechanisms and interventions. Recent studies have highlighted thyroid hormone analogs and derivatives as potential agents able to counteract such pathologies. In this study, in rats receiving
Elena Grasselli et al.
Journal of hepatology, 54(6), 1230-1236 (2010-12-15)
Previous studies have demonstrated that 3,5-L-diiodothyronine (T(2)) is able to prevent lipid accumulation in the liver of rats fed a high-fat diet. Whether this effect is due to a direct action of T(2) on the liver has not been elucidated.
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