C9012

Bis(cyclohexanone)oxaldihydrazone

≥95% purity (TLC), powder

• Sinônimo(s): Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)
• Fórmula empírica (Notação de Hill): C₁₄H₂₂N₄O₂
• Número CAS: 370-81-0
• Peso molecular: 278.35
• Beilstein: 2388004
• Número CE: 206-729-2
• Número MDL: MFCD00001659
• Código UNSPSC: 12171500
• ID de substância PubChem: 24893128
• NACRES: NA.47

Propriedades

• product name: Bis(cyclohexanone)oxaldihydrazone, ≥95% (TLC)
• Nível de qualidade: 100
• Ensaio: ≥95% (TLC)
• forma: powder
• técnica(s): titration: suitable
• cor: white/clear to off-white
• pf: 210-214 °C (lit.)
• solubilidade: acetic acid: 50 mg/mL, colorless to very faintly brown
• aplicação(ões): diagnostic assay manufacturing; hematology; histology
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
• InChI: 1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
• chave InChI: DSRJIHMZAQEUJV-UHFFFAOYSA-N

Descrição

Aplicação

• Bis(cyclohexanone)oxaldihydrazone (Cuprizone) has been used in mice to study the effect of NG2 (neural/glial antigen 2) proteoglycan on toxic-induced demyelination.
• It has been used to induce demyelination in mice.
• It has been used to study cuprizone-induced demyelination and remyelination in the corpus callosum of mice.

Ações bioquímicas/fisiológicas

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)