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Documentos Principais

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C7397

Sigma-Aldrich

Cyclophosphamide monohydrate

ISOPAC®

Sinônimo(s):

2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan

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About This Item

Fórmula empírica (Notação de Hill):
C7H15Cl2N2O2P · H2O
Número CAS:
6055-19-2
Peso molecular:
279.10
Beilstein:
4678992
Número CE:
200-015-4
Número MDL:
MFCD00149395
Código UNSPSC:
51112507
ID de substância PubChem:
24892961
NACRES:
NA.25

Nível de qualidade

100

Ensaio

97.0-103.0% (HPLC)

Formulário

powder

pf

49-51 °C (lit.)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

chave InChI

PWOQRKCAHTVFLB-UHFFFAOYSA-N

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Aplicação

Cyclophosphamide, a nitrogen mustard DNA alkylating agent, is used to study its mechanisms of action as an anticancer and antiimmunity drug.

Ações bioquímicas/fisiológicas

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.

Embalagem

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.

Atenção

Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.

Reconstituição

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Informações legais

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC de

Nº do produto
Descrição
Preços

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Frases de perigo

H301,H340,H350,H360FD

Classificações de perigo

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
MKCN3646
MKCL2547
MKCJ4697
MKCG5464
MKCF1756

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Sigma-Aldrich

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Doxorrubicina 98.0-102.0% (HPLC)

Sigma-Aldrich

D1515

Doxorrubicina

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Autoimmunity reviews, 12(2), 174-194 (2012-09-18)
Lupus nephritis remains one of the most severe manifestations of systemic lupus erythematosus associated with considerable morbidity and mortality. A better understanding of the pathogenesis of lupus nephritis is an important step in identifying more targeted and less toxic therapeutic
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Seminars in oncology, 39(6), 683-693 (2012-12-05)
Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative therapy for many hematologic and immunologic diseases. Further, partial or full donor hematopoietic chimerism following alloSCT may be sufficient to guarantee immunologic tolerance to solid organs from the same donor
Charlotte Israelsson et al.
Journal of neuroscience research, 93(10), 1519-1525 (2015-06-13)
A major component of the damaging effect after traumatic brain injury (TBI) is activation of the inflammatory system. In particular, chemokines and chemokine-regulated factors become activated in resident brain cells and signal to different invading immune cells. For evaluation of
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