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C1671

Sigma-Aldrich

Chlorprothixene hydrochloride

Sinônimo(s):

2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C18H18ClNS · HCl
Número CAS:
6469-93-8
Peso molecular:
352.32
Número CE:
229-289-3
Número MDL:
MFCD01941605
Código UNSPSC:
12352200
ID de substância PubChem:
24278300
NACRES:
NA.77

forma

powder

Nível de qualidade

100

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.CN(C)CC\C=C1\c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H/b14-7-;

chave InChI

YWKRLOSRDGPEJR-KIUKIJHYSA-N

Informações sobre genes

human ... DRD2(1813) , DRD3(1814) , HTR2A(3356) , HTR2C(3358)

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Descrição geral

Chlorprothixene is a neuroleptic drug, which belongs to thioxanthene group. It has anticholinergic effects. Chlorprothixene might be associated with obstructive jaundice and parkinsonism. It is used to treat psychosis.

Aplicação

Chlorprothixene hydrochloride has been used to study its exposure effects on learning and memory of rats.

Ações bioquímicas/fisiológicas

D2 dopamine receptor antagonist; blocks a subset of GABAA receptors in rat cortex that is also blocked by clozapine; thioxanthine antipsychotic.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P301 + P310

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Manavu Tohmi et al.
iScience, 26(1), 105778-105778 (2023-01-04)
Despite its importance, the development of higher visual areas (HVAs) at the cellular resolution remains largely unknown. Here, we conducted 2-photon calcium imaging of mouse HVAs lateromedial (LM) and anterolateral (AL) and V1 to observe developmental changes in visual response
V Hadjimitova et al.
Pharmacology & toxicology, 84(4), 170-173 (1999-05-05)
The effect of some psychotropic drugs on the activity of macrophages to produce superoxide radicals during phagocytosis was tested. Three-cyclic antidepressants, imipramine and amitriptyline, and the thioxanthene neuroleptic, chlorprothixene, were studied. The superoxide production was measured by luminol-dependent chemiluminescence. The
M Froimowitz et al.
Journal of medicinal chemistry, 36(15), 2219-2227 (1993-07-23)
Conformational analyses have been performed on several phenothiazine and thioxanthene dopamine antagonists using the MM2-87 program and parameter set. The compounds that were examined are thioridazine (2), methotrimeprazine (3), cis- and trans-chlorprothixene, and a piperidylidene derivative of chlorprothixene. In addition
Joshua B Melander et al.
Cell reports, 37(6), 109972-109972 (2021-11-11)
Cortical function relies on the balanced activation of excitatory and inhibitory neurons. However, little is known about the organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons. Here, we use the excitatory postsynaptic marker PSD-95, fluorescently labeled at
Desk Reference of Clinical Pharmacology, Second Edition (1997)
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