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C117

Sigma-Aldrich

5-Carboxamidotryptamine maleate salt

powder, ≥98% (HPLC)

Sinônimo(s):

5-CT, AH-21467

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About This Item

Fórmula empírica (Notação de Hill):
C11H13N3O · C4H4O4
Número CAS:
74885-72-6
Peso molecular:
319.31
Número MDL:
MFCD00069224
Código UNSPSC:
12352116
ID de substância PubChem:
24278086
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

cor

white to off-white

solubilidade

H2O: 10 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC(=O)\C=C/C(O)=O.NCCc1c[nH]c2ccc(cc12)C(N)=O

InChI

1S/C11H13N3O.C4H4O4/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10;5-3(6)1-2-4(7)8/h1-2,5-6,14H,3-4,12H2,(H2,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

chave InChI

PZQZSWAOVAMBQM-BTJKTKAUSA-N

Informações sobre genes

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR2A(3356) , HTR2C(3358) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)
rat ... Htr7(65032)

Ações bioquímicas/fisiológicas

Agonist at 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 serotonin receptors.

produto comparável

Nº do produto
Descrição
Preços

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(3), 3870-3886 (2018-12-07)
According to early models of GPCR signaling, G proteins only interact with activated receptors. However, some GPCRs were shown to assemble with G proteins before receptor activation, in accordance with more recent models. Previously, we found that the 5-HT7 receptor
Omkar L Patkar et al.
Addiction biology, 24(4), 652-663 (2018-07-20)
Repeated cycles of binge-like alcohol consumption and abstinence change the activity of several neurotransmitter systems. Some of these changes are consolidated following prolonged alcohol use and are thought to play an important role in the development of dependence. We have
Kirsten E Hoff et al.
PloS one, 13(8), e0203198-e0203198 (2018-08-30)
Mutations in mitochondrial DNA (mtDNA) have been linked to a variety of metabolic, neurological and muscular diseases which can present at any time throughout life. MtDNA is replicated by DNA polymerase gamma (Pol γ), twinkle helicase and mitochondrial single-stranded binding
Ayako Moritomo et al.
Bioorganic & medicinal chemistry, 22(15), 4323-4337 (2014-06-12)
We previously reported that the novel dual 5-HT₂B and 5-HT7 receptor antagonist N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (4) exerted a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs. To develop a synthetic strategy, we performed docking studies of lead compound 4 bound
W L Bacon et al.
The Journal of pharmacology and experimental therapeutics, 294(2), 672-679 (2000-07-20)
The 5-hydroxytryptamine(7) (5-HT(7)) receptor was originally defined by molecular biology techniques. The 5-HT(7) receptor protein and mRNA are found in brain areas, such as the CA3 subfield of the hippocampus, that are involved in various neuropsychiatric disease states. No functional
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