C0737

Cilostazol

≥98% (HPLC), powder

• Sinônimo(s): 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC 13013, OPC 21, Pletaal
• Fórmula empírica (Notação de Hill): C₂₀H₂₇N₅O₂
• Número CAS: 73963-72-1
• Peso molecular: 369.46
• Número MDL: MFCD00866780
• Código UNSPSC: 41106305
• ID de substância PubChem: 24278291
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: off-white
• solubilidade: DMSO: 10 mg/mL, clear
• originador: Otsuka Pharma
• cadeia de caracteres SMILES: O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1
• InChI: 1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
• chave InChI: RRGUKTPIGVIEKM-UHFFFAOYSA-N
• Informações sobre genes: human ... PDE3A(5139) , PDE3B(5140)

Descrição

Descrição geral

Cilostazol prevents platelet aggregation and has vasodilatory properties. It is used to treat chronic arterial disease and intermittent claudication. Cilostazol has antiproliferative effects and improves the properties of prostacyclin. It regulates cell proliferation, stimulates cyclic adenosine monophosphate (cAMP) level and induces cyclic AMP-dependent protein kinase.

Aplicação

Cilostazol has been used:

• to reduce Madin–Darby cell line (MDCK) proliferation through c-Myc down-regulation
• in the in vitro assessment of toxin delivery in T84 intestinal epithelial cells
• to induce adenosine triphosphate (ATP) release in white adipocytes

Ações bioquímicas/fisiológicas

Phosphodiesterase III (PDE3) inhibitor

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Otsuka Pharma. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Warning
• Frases de perigo: H361d
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)