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B8279

Sigma-Aldrich

Ro-20-1724

≥98% (HPLC), solid, cAMP phosphodiesterase inhibitor

Sinônimo(s):

Ro 20-1724

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About This Item

Fórmula empírica (Notação de Hill):
C15H22N2O3
Número CAS:
29925-17-5
Peso molecular:
278.35
Número MDL:
MFCD00077397
Código UNSPSC:
41106305
ID de substância PubChem:
24278195
NACRES:
NA.77

Nome do produto

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, solid

fonte biológica

synthetic (organic)

Ensaio

≥98% (HPLC)

Formulário

solid

solubilidade

ethanol: 7 mg/mL
H2O: insoluble

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CCCCOc1cc(CC2CNC(=O)N2)ccc1OC

InChI

1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)

chave InChI

PDMUULPVBYQBBK-UHFFFAOYSA-N

Informações sobre genes

human ... LITAF(9516) , PDE4B(5142) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
rat ... Pde4a(25638)

Aplicação

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one has been used:
  • as a cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitor to treat cells for the determination of intracellular cAMP levels
  • as a component of serum-free medium
  • as phosphodiesterase inhibitor in order to study the effects of protease-activated receptor-1 (PAR-1) activation on cAMP levels

Ações bioquímicas/fisiológicas

Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
SLCL2404
SLCH3208
SLCD4881
SLCB4454
SLBZ0900

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Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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