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B6929

Sigma-Aldrich

Lys-(des-Arg9, Leu8)-Bradykinin trifluoroacetate salt

≥95%

Sinônimo(s):

des(Arg10, Leu9)-Kallidin

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About This Item

Fórmula empírica (Notação de Hill):
C47H75N13O11
Peso molecular:
998.18
Número MDL:
MFCD00274007
Código UNSPSC:
12352203
ID de substância PubChem:
329773287
NACRES:
NA.32

Ensaio

≥95%

forma

powder

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCCN)C(O)=O

InChI

1S/C47H75N13O11/c1-28(2)24-33(46(70)71)56-42(66)36-17-10-21-58(36)44(68)34(27-61)57-40(64)32(25-29-12-4-3-5-13-29)54-38(62)26-53-41(65)35-16-9-22-59(35)45(69)37-18-11-23-60(37)43(67)31(15-8-20-52-47(50)51)55-39(63)30(49)14-6-7-19-48/h3-5,12-13,28,30-37,61H,6-11,14-27,48-49H2,1-2H3,(H,53,65)(H,54,62)(H,55,63)(H,56,66)(H,57,64)(H,70,71)(H4,50,51,52)/t30-,31-,32-,33-,34-,35-,36-,37-/m0/s1

chave InChI

AGTPZUQKOYEAOH-MDKUUQCZSA-N

Informações sobre genes

human ... BDKRB1(623)
mouse ... BDKRB1(12061)
rat ... BDKRB1(81509)

Amino Acid Sequence

Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu

Ações bioquímicas/fisiológicas

B1 bradykinin receptor antagonist.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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T MacNeil et al.
Canadian journal of physiology and pharmacology, 75(6), 735-740 (1997-06-01)
We developed a functional assay to evaluate the activity of kinin peptides at the human and mouse bradykinin (BK) B1 receptors. The photoprotein aequorin expressed in 293-AEQ17 cells was used to measure calcium mobilization due to activation of the human
S P Zhang et al.
Life sciences, 62(25), 2303-2314 (1998-07-03)
Bradykinin (BK) receptors are involved in pain and inflammation. Two BK receptor subtypes, B1 and B2, have been defined based on their pharmacological properties. Both B1 and B2 receptors are G-protein coupled membrane receptors. B1 receptors are present in smooth
J G Menke et al.
The Journal of biological chemistry, 269(34), 21583-21586 (1994-08-26)
A cDNA clone encoding a human B1 bradykinin receptor was isolated from a human embryonic lung fibroblast cDNA library by expression cloning. The photoprotein aequorin was utilized as an indicator of the ability of the B1 receptor agonist [des-Arg10]kallidin to
Man Zhang et al.
American journal of physiology. Cell physiology, 296(6), C1364-C1372 (2009-04-03)
Bradykinin (BK) is an endogenous peptide with diverse biological actions and is considered to be an important mediator of the inflammatory response in both the peripheral and the central nervous systems. BK has attracted recent interest as a potential mediator

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