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B3756

Sigma-Aldrich

8-Bromoadenosine 5′-triphosphate sodium salt

≥90% (HPLC)

Sinônimo(s):

8-Br-ATP

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About This Item

Fórmula linear:
C10H15N5O13P3Br
Número CAS:
81035-56-5
Peso molecular:
586.08
Número MDL:
MFCD00070102
Código UNSPSC:
41106305
ID de substância PubChem:
24891733
NACRES:
NA.51

Nível de qualidade

200

Ensaio

≥90% (HPLC)

Formulário

powder

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Na].Nc1ncnc2n(C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O)c(Br)nc12

InChI

1S/C10H15BrN5O13P3.Na.H/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21);;

chave InChI

BWSZHFBRMPXNSH-UHFFFAOYSA-N

Aplicação

8-Bromoadenosine 5′-triphosphate (8-Br-ATP) is as an ATP analogue used in conjunction with other ATP analogues to study and resolve ATP-site binding effects on receptor and enzyme function and specificity.

Ações bioquímicas/fisiológicas

P2X purinoceptor agonist similar in reactivity to ATP.

Ligação

8-Bromo form of adenosine 5′-triphosphate.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
SLBM6173V
SLBC8828V
129K5055
015K7036
093H7811

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Lisa S Chen et al.
The Journal of biological chemistry, 279(39), 40405-40411 (2004-07-22)
The nucleotide substrate specificity of yeast poly(A) polymerase (yPAP) toward various C-2- and C-8-modified ATP analogs was examined. 32P-Radiolabeled RNA oligonucleotide primers were incubated with yPAP in the absence of ATP to assay polyadenylation using unnatural ATP substrates. The C-2-modified
Hiroyuki Iwamoto
Journal of muscle research and cell motility, 29(1), 45-55 (2008-07-11)
Previous studies using solubilized fragments of myosins have shown that an ATP analogue, 8-bromoadenosine triphosphate (8-Br-ATP) is a poor substrate for fast skeletal myosin isoform. We further characterized the analogue by using vertebrate skeletal muscle fibers. In the absence of
M Picher et al.
Biochemical pharmacology, 51(11), 1453-1460 (1996-06-14)
Pharmacologists are becoming more and more aware of the possibility that certain ATP analogues currently used to classify the P2-purinoceptors are dephosphorylated by ectonucleotidases. In this study, we provide evidence that in the vascular system, these purine analogues are hydrolysed
J Stutchfield et al.
FEBS letters, 262(2), 256-258 (1990-03-26)
We have recently characterised the presence of a Ca2(+)-mobilising receptor for ATP which stimulates exocytosis in differentiated HL60 cells. Here we demonstrate that the undifferentiated HL60 cells also respond to extracellular ATP by stimulating an increase in inositol phosphates and
S Maruta et al.
European journal of biochemistry, 256(1), 229-237 (1998-09-24)
Numerous analytical experiments have shown that, in solution, ATP analogues with bulky substitutions at the eighth position of the adenine ring predominantly assume the syn conformation with respect to the adenine-ribose bond. Two such analogues, 3'-O-(N-methylanthraniloyl)-8-azido-ATP (Mant-8-N3-ATP) and 8-Br-ATP, were
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