A1388

Adenosine 5′-[γ-thio]triphosphate tetralithium salt

≥75% (HPLC), powder

• Sinônimo(s): ATP-γ-S, Adenosine 5′-(3-thiotriphosphate) tetralithium salt, Ado-5′-PPP[S]
• Fórmula empírica (Notação de Hill): C₁₀H₁₂Li₄N₅O₁₂P₃S
• Número CAS: 93839-89-5
• Peso molecular: 546.98
• Beilstein: 6265083
• Número CE: 298-862-8
• Número MDL: MFCD00077293
• Código UNSPSC: 41106305
• eCl@ss: 32160414
• ID de substância PubChem: 24890536
• NACRES: NA.51

Propriedades

• fonte biológica: synthetic (organic)
• Ensaio: ≥75% (HPLC)
• Formulário: powder
• cor: off-white
• solubilidade: H₂O: 25 mg/mL
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [Li+].[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
• chave InChI: DWQFDOIBOYDYKH-KWIZKVQNSA-J

Descrição

Aplicação

Adenosine 5′-[γ-thio]triphosphate tetralithium salt has been used to treat the pollen grains to determine the inhibitory effect of adenosine triphosphate (ATP) or its hydrolysis product. It has also been used to select thiophosphorylate target protein.

Ações bioquímicas/fisiológicas

Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca²⁺-activated K⁺ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.

Outras notas

Non-hydrolyzable ATP analog

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves