A9135

Ethyl arachidonate

≥98.5% (GC), liquid

• Sinônimo(s): 5,8,11,14-Eicosatetraenoic acid ethyl ester, Arachidonic acid ethyl ester
• Fórmula empírica (Notação de Hill): C₂₂H₃₆O₂
• Número CAS: 1808-26-0
• Peso molecular: 332.52
• Número MDL: MFCD00038340
• Código UNSPSC: 12352211
• ID de substância PubChem: 24891398
• NACRES: NA.25

Propriedades

• fonte biológica: fungus
• Ensaio: ≥98.5% (GC)
• forma: liquid
• grupo funcional: ester
• tipo de lipídio: omega FAs
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCC
• InChI: 1S/C22H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h8-9,11-12,14-15,17-18H,3-7,10,13,16,19-21H2,1-2H3/b9-8-,12-11-,15-14-,18-17-
• chave InChI: SNXPWYFWAZVIAU-GKFVBPDJSA-N

Descrição

Ações bioquímicas/fisiológicas

Arachidonic acid (AA) is an unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, contraction, chemotaxis, and cell proliferation, differentiation and apoptosis. AA has been demonstrated to bind to the α subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.

Embalagem

Sealed ampule.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves